Sprayable anti-infective and anti-biofilm coatings for industrial, agricultural, and consumer applications

适用于工业、农业和消费应用的可喷涂抗感染和抗生物膜涂层

• 批准号: 570723-2021
• 负责人: Hoare, Todd
• 金额: $ 16.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=720697
• 关键词: Sprayable; anti; infective; biofilm; coatings

The COVID-19 pandemic and increasing concerns over emerging antibiotic resistant bacteria have made the development of new approaches to deactivate pathogens on surfaces increasingly critical. The eradication of dense biofilms (combinations of bacteria and extracellular polymers) that can develop in areas as diverse as biomedical implants to bioreactors to oil pipelines is even more challenging than killing a single bacteria, with all of the (very few) products now available for biofilm sterilization requiring the use of very corrosive or environmentally toxic components. While some engineered surfaces have demonstrated potential for the long-term prevention of biofilm formation, all current approaches have drawbacks in terms of their longevity and/or ability to be applied at the point-of-use on diverse surfaces instead of directly during manufacturing. In this Alliance project, a team of researchers from McMaster University will work closely with Suncor Energy to develop sprayable coatings that can adhere to a variety of surfaces to facilitate long-term anti-microbial and anti-biofilm activity over time periods ranging from a few days to several months, depending on the target application. By developing techniques to integrate bioactive formulations identified by Suncor for highly effective bacteria/biofilm deactivation into sprayable polymer and/or hydrogel-based precursor solutions thatcan form thin films upon drying, we aim to develop environmentally-friendly (and in some cases fully bio-based) coatings that can immobilize, stabilize, and control the release of the bioactive agents over time, facilitating surface sterilization relevant to use in agriculture (preventing plant disease to enhance crop yields), consumer products (preventing disease transmission via high-touch surfaces like countertops, door knobs, or transit rails), industrial equipment (maintaining long-term operation of fermentation reactors or oil pipelines), and other applications. The close collaboration between the Suncor and McMaster teams, including on-site work at McMaster by Suncor employees, will ensure an integrated project workflow ideal to collaboratively develop a line of sprayable anti-microbial coatings with health and economic benefits to Canada.

COVID-19大流行以及对新出现的抗生素耐药性细菌的日益担忧使得开发灭活表面病原体的新方法变得越来越重要。消除致密的生物膜（细菌和细胞外聚合物的组合），可以在生物医学植入物到生物反应器到石油管道等不同领域发展，甚至比杀死单一细菌更具挑战性，现在所有（很少）可用于生物膜灭菌的产品都需要使用非常腐蚀性或环境毒性的成分。虽然一些工程化表面已经证明了长期防止生物膜形成的潜力，但所有当前的方法在其寿命和/或在不同表面上的使用点而不是直接在制造期间施加的能力方面都具有缺点。在这个联盟项目中，来自麦克马斯特大学的一组研究人员将与森科尔能源公司密切合作，开发可喷涂的涂层，这些涂层可以粘附在各种表面上，以促进长期的抗微生物和抗生物膜活性，时间从几天到几个月不等，具体取决于目标应用。通过开发技术，将Suncor确定的高效细菌/生物膜灭活的生物活性制剂整合到可喷涂的聚合物和/或基于水凝胶的前体溶液中，这些溶液在干燥后可以形成薄膜，我们的目标是开发环境友好的（和在某些情况下完全生物基的）涂层，其可以随时间推移抑制、稳定和控制生物活性剂的释放，促进与农业使用相关的表面消毒（预防植物病害以提高作物产量），消费品（防止疾病通过高接触表面传播，如台面、门把手或运输轨道），工业设备（维持发酵反应器或输油管道的长期运行）等应用。森科尔和麦克马斯特团队之间的密切合作，包括森科尔员工在麦克马斯特的现场工作，将确保一个综合的项目工作流程，理想的合作开发一系列可喷涂的抗微生物涂料，为加拿大带来健康和经济效益。