Photodynamically-active coatings for extended disinfection of high-touch surfaces to combat COVID-19

光动力活性涂层可对频繁接触的表面进行长期消毒，以对抗 COVID-19

• 批准号: 552688-2020
• 负责人: Hoare, Todd
• 金额: $ 3.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=703630
• 关键词: Photodynamically; active; coatings; extended; disinfection

While social distancing protocols between people appear to be most critical to prevent SARS-CoV-2 transmission, the potential for surface-to-person transmission remains a key risk factor associated with community spread of COVID-19. For the broader population, key surfaces of concern include doorknobs/door handles, handrails on stairwells or public transit, and keypads on payment machines. Additional concerns are present in locations like schools and long-term care facilities given the inherent challenges in ensuring children and cognitively/physically-impaired older adults follow proper handwashing protocols to reduce surface transmission risk. While regular disinfection effectively kills SARS-CoV-2, existing disinfection protocols have minimal residual activity and thus require labour-intensive regular re-application. Developing a safe sprayable coating that can maintain effective disinfection of high-touch surfaces over up to one week without interim intervention would thus dramatically reduce the risks of community spread of SARS-CoV-2 and other diseases. This project aims to create such coatings through a partnership between Suncor and Dr. Todd Hoare (McMaster University). Suncor has a decade of experience in formulating sprayable emulsions and, more recently (in collaboration with Hoare), sprayable coatings based on food-grade materials that can effectively kill a broad spectrum of plant-based pathogens upon exposure to sunlight (often achieving complete eradication of pathogens). Herein, we aim to collaboratively re-engineer these agricultural coatings to address key challenges specific to high-touch surfaces, specifically increasing coating adhesion/stability as well as ensuring that all relevant indoor and outdoor light sources can effectively stimulate rapid viral deactivation. Following, we will validate the performance of the coatings in practical applications, with a successful result leading to regulatory filings and, ultimately, manufacturing and commercialization by Suncor (leveraging its existing agricultural infrastructure). We anticipate such coatings will offer a safe and convenient disinfection strategy for reducing the risk of community disease spread.

虽然人与人之间的社交距离协议似乎是预防SARS-CoV-2传播的最关键因素，但人与人之间传播的可能性仍然是与COVID-19社区传播相关的关键风险因素。 对于更广泛的人群，关注的关键表面包括门把手/门把手，楼梯间或公共交通工具上的扶手，以及付款机上的广告。 在学校和长期护理设施等地点存在其他问题，因为在确保儿童和认知/身体受损的老年人遵守适当的洗手协议以减少表面传播风险方面存在固有的挑战。 虽然定期消毒可以有效杀死SARS-CoV-2，但现有的消毒方案具有最小的残留活性，因此需要劳动密集型的定期重新应用。 因此，开发一种安全的可喷涂涂层，可以在长达一周的时间内保持高接触表面的有效消毒，而无需临时干预，这将大大降低SARS-CoV-2和其他疾病的社区传播风险。 该项目旨在通过森科尔和托德霍尔博士（麦克马斯特大学）之间的伙伴关系，创造这样的涂料。 Suncor在配制可喷涂乳液方面拥有十年的经验，最近（与Hoare合作），基于食品级材料的可喷涂涂料可以在暴露于阳光下时有效杀死广泛的植物病原体（通常实现病原体的完全根除）。 在此，我们的目标是合作重新设计这些农业涂料，以解决高接触表面特有的关键挑战，特别是提高涂层粘附力/稳定性，并确保所有相关的室内和室外光源都能有效地刺激快速病毒灭活。 接下来，我们将验证涂料在实际应用中的性能，成功的结果导致监管备案，并最终由Suncor（利用其现有的农业基础设施）制造和商业化。 我们预计这种涂层将提供一种安全方便的消毒策略，以降低社区疾病传播的风险。