Photodynamically-active coatings for extended disinfection of high-touch surfaces to combat COVID-19

光动力活性涂层可对频繁接触的表面进行长期消毒，以对抗 COVID-19

• 批准号: 552688-2020
• 负责人: Hoare, Todd
• 金额: $ 3.64万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2020
• 资助国家: 加拿大
• 起止时间: 2020-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=703630
• 关键词: Photodynamically; active; coatings; extended; disinfection

While social distancing protocols between people appear to be most critical to prevent SARS-CoV-2 transmission, the potential for surface-to-person transmission remains a key risk factor associated with community spread of COVID-19. For the broader population, key surfaces of concern include doorknobs/door handles, handrails on stairwells or public transit, and keypads on payment machines. Additional concerns are present in locations like schools and long-term care facilities given the inherent challenges in ensuring children and cognitively/physically-impaired older adults follow proper handwashing protocols to reduce surface transmission risk. While regular disinfection effectively kills SARS-CoV-2, existing disinfection protocols have minimal residual activity and thus require labour-intensive regular re-application. Developing a safe sprayable coating that can maintain effective disinfection of high-touch surfaces over up to one week without interim intervention would thus dramatically reduce the risks of community spread of SARS-CoV-2 and other diseases. This project aims to create such coatings through a partnership between Suncor and Dr. Todd Hoare (McMaster University). Suncor has a decade of experience in formulating sprayable emulsions and, more recently (in collaboration with Hoare), sprayable coatings based on food-grade materials that can effectively kill a broad spectrum of plant-based pathogens upon exposure to sunlight (often achieving complete eradication of pathogens). Herein, we aim to collaboratively re-engineer these agricultural coatings to address key challenges specific to high-touch surfaces, specifically increasing coating adhesion/stability as well as ensuring that all relevant indoor and outdoor light sources can effectively stimulate rapid viral deactivation. Following, we will validate the performance of the coatings in practical applications, with a successful result leading to regulatory filings and, ultimately, manufacturing and commercialization by Suncor (leveraging its existing agricultural infrastructure). We anticipate such coatings will offer a safe and convenient disinfection strategy for reducing the risk of community disease spread.

尽管人们之间的社会距离协议似乎对于防止SARS-COV-2传播最为重要，但表面对手传播的潜力仍然是与Covid-19的社区传播相关的关键风险因素。 对于更广泛的人口，关注的关键表面包括门把手/门把手，楼梯间或公共交通上的扶手以及付款机上的键盘。 考虑到确保儿童和认知/身体受损的老年人遵循适当的洗手方案以降低表面传播风险的固有挑战，在学校和长期护理设施等地点存在其他问题。 虽然常规消毒有效地杀死了SARS-COV-2，但现有的消毒协议具有最小的残留活性，因此需要进行劳动密集型的常规重新应用。 开发可安全的喷涂涂层，可以在不临时干预的情况下最多有效地对高接触表面进行有效消毒，从而大大降低SARS-COV-2和其他疾病的社区传播风险。 该项目旨在通过Suncor和Todd Hoare博士（McMaster University）之间的合作伙伴关系来创建此类涂料。 Suncor在制定可喷涂的乳液方面拥有十年的经验，以及最近（与Hoare合作），基于食品级材料的可喷涂涂料，可以有效地杀死暴露于阳光后（通常可以完全消除病原体）时杀死广泛的植物性病原体。 在本文中，我们旨在协作重新设计这些农业涂料，以应对针对高接触表面的主要挑战，特别是增加了涂层粘附/稳定性，并确保所有相关的室内和室外光源都可以有效地刺激快速的病毒式脱位。 随后，我们将验证涂料在实际应用中的性能，并成功地导致了监管文件，并最终通过Suncor（利用其现有的农业基础设施）来制造和商业化。 我们预计，这种涂料将提供安全便捷的消毒策略，以减少社区疾病传播的风险。