Dairy microfluidic devices for detection of antibiotics

用于检测抗生素的乳制品微流体装置

• 批准号: 570519-2021
• 负责人: Collier, Christopher
• 金额: $ 7.29万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=722465
• 关键词: Dairy; microfluidic; devices; detection; antibiotics

Antibiotic detection in dairy is very important. If dairy farmers ship contaminated milk, they risk heavy monetary fines. Additionally, antibiotics in food can lead to allergic reaction and antibiotic resistance. This project will develop a dairy microfluidic device. The device is developed through collaboration between Agrisan and Dr. Collier's research group at The University of British Columbia. The goals for the device development are to detect multiple antibiotics (as antibiotics are given to cattle in cocktails), to have user-friendly operation (for eventual on-farm use), and to avoid false positives. These goals will be achieved through a set of research tasks involving several graduate students. These tasks are as follows: 1. Characterizing antibiotic flow velocity. This is to understand separation behaviour of multiple analytes. 2. Performance of system with multiple antibiotics. This is to demonstrate this fundamental operation for a cocktail of antibiotics, as in the real world application. Task 3: Scripting of operations. This is to clarify user input. Task 4: Implementation as touch screen. These tasks ensure user-friendly operation. Task 5: Miniaturization. This is to ensure small footprint for on-farm operation. Task 6: Integration of wavelengths measurements. This is assist with identifying false positives. Task 7: Experimentally demonstrating robustness to false positives. This will show the ultimate operation of the microfluidic dairy device. The results of this project will have far-reaching benefits to Canada's economy and health.

乳品中的抗生素检测非常重要。如果奶农运输受污染的牛奶，他们将面临巨额罚款。此外，食物中的抗生素可导致过敏反应和抗生素耐药性。本项目将开发一种乳品微流控装置。该设备是由Agrisan和Collier博士在不列颠哥伦比亚省大学的研究小组合作开发的。该设备开发的目标是检测多种抗生素（因为抗生素是在鸡尾酒中给牛使用的），具有用户友好的操作（最终在农场使用），并避免假阳性。这些目标将通过一系列涉及几个研究生的研究任务来实现。这些任务如下：1.抗生素流速的特征。这是为了了解多种分析物的分离行为。2.具有多种抗生素的系统的性能。这是为了展示抗生素鸡尾酒的基本操作，就像在真实的世界中的应用一样。任务3：操作脚本。这是为了澄清用户输入。任务4：实现为触摸屏。这些任务确保了用户友好的操作。任务5：小型化。这是为了确保农场作业占地面积小。任务6：波长测量的积分。这有助于识别误报。任务7：通过实验证明对误报的鲁棒性。这将显示微流体乳品装置的最终操作。该项目的成果将对加拿大的经济和健康产生深远的影响。