Injectable, gelable and degradable system for protein delivery in partnership with Mannin

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The goal of this partnership is to create a drug delivery system for a new treatment that is physician and patient friendly for use in a glaucoma application. If successful, this will help alleviate the direct and indirect costs associated with glaucoma while growing the national biomanufacturing capabilities within Canada. Mannin Research has a number of biologically-based molecules that have shown preliminary potential for treating eye diseases and conditions, particularly glaucoma. However, the nature of these compounds leads to the potential for degradation, making appropriate delivery methods critical to their successful application. The goal of this proposal is to develop a delivery system for Mannin's formulation that is suitable for a glaucoma treatment. At McMaster, through the 20/20 NSERC Ophthalmic Materials Research Network and the ORF-funded C20/20 Innovation Hub, we have established an international reputation for the development and validation of new delivery methods for getting drugs into the eye using a team approach. Multidisciplinary projects involving polymer development, drug release and biological characterization as well as biological validation of the delivery system require teams with broad expertise and project management. All members of the team have expertise in the development of ophthalmic delivery systems; the team approach will capitalize on the strengths of each of the members (polymer science and chemistry, drug delivery validation, in vitro and in validation) to ensure a successful outcome. Through previous researcher collaborations, Mannin and the network members have worked on other applications. This existing relationship allows us to execute quickly on the research goals outlined in this proposal.