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Market Assessment - Strategic assessment of a therapeutic, bioactive contact lens

市场评估 - 治疗性生物活性隐形眼镜的战略评估

基本信息

批准号：
560512-2021
负责人：
Sheardown, Heather
金额：
$ 1.09万
依托单位：
McMaster University
依托单位国家：
加拿大
项目类别：
Idea to Innovation
财政年份：
2020
资助国家：
加拿大
起止时间：
2020-01-01 至 2021-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=700573
关键词：
Market Assessment Strategic assessment therapeutic

项目摘要

Diseases of the cornea, which ultimately cause corneal scarring, are the third most common cause of blindness worldwide. Additionally, corneal injuries and ulcerations, which also lead to corneal scars, result in at least an additional 2 million new cases of monocular blindness. Corneal wound healing is a complex process that requires coordination of various processes including cell migration, cell proliferation, re-stratification, as well as matrix deposition and tissue remodeling. This remodeling is known to be mediated by a number of growth factors, including epidermal growth factor (EGF), which are central to the proper management of corneal wounds. In an effort to aid healing, standard contact lenses are used to bandage the corneal surface after injury; these have limited therapeutic benefit. We propose a bandage silicone hydrogel contact lens with tethered EGF that can accelerate the corneal wound healing response and more importantly control the remodelling process and progression of corneal fibrosis, effectively reducing scarring while maintaining the high oxygen permeability needed for ocular health. This technology could be used in the frontline treatment of cornea-related injury, preventing corneal scarring and reducing associated vision loss and the need for corneal transplants, improving patient outcomes. We request funds to complete a Market Assessment to determine the market segments for this product and what barriers may exist to entry, which will allow us to then create a business plan for successful technology transfer and commercialization.

最终导致角膜瘢痕形成的角膜疾病是全世界第三大最常见的致盲原因。此外，角膜损伤和溃疡也会导致角膜瘢痕，导致至少另外200万例单眼失明的新病例。角膜伤口愈合是一个复杂的过程，需要协调各种过程，包括细胞迁移、细胞增殖、再分层以及基质沉积和组织重塑。已知这种重塑是由许多生长因子介导的，包括表皮生长因子（EGF），其是角膜伤口的适当管理的核心。为了帮助愈合，标准的隐形眼镜被用来在受伤后包扎角膜表面;这些具有有限的治疗益处。我们提出了一种具有束缚EGF的绷带硅水凝胶接触透镜，其可以加速角膜伤口愈合反应，更重要的是控制角膜纤维化的重塑过程和进展，有效地减少瘢痕形成，同时保持眼睛健康所需的高透氧性。该技术可用于角膜相关损伤的一线治疗，预防角膜瘢痕形成，减少相关视力丧失和角膜移植需求，改善患者预后。我们要求资金完成市场评估，以确定该产品的细分市场以及可能存在的进入障碍，这将使我们能够制定成功的技术转让和商业化的商业计划。