Lab2Market - Investigating the potential appetite-supressing effects of a novel cytokinin.

Lab2Market - 研究一种新型细胞分裂素的潜在食欲抑制作用。

• 批准号: 571253-2022
• 负责人: Belsham, Denise
• 金额: $ 1.46万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=729106
• 关键词: Lab2Market; Investigating; potential; appetite; supressing

A complex neuronal system has evolved to maintain energy balance required for a healthy body weight, but it is biased towards weight gain in times of plenty. Exactly how the brain senses nutrients is not yet understood, but it is now recognized that the brain can sense fat and carbohydrates through specific neurons and can regulate feeding by modulating the expression of neuropeptides in the brain. However, what exactly causes weight gain, often by excess levels of fat and sugar intake, is a tremendous problem in the fight against obesity. Interestingly, we have discovered a plant-derived molecule that decreases food intake in mice, even when they were consuming a high fat diet. The decrease in food intake was sustained over weeks and was effective in both male and female mice. Therefore major efforts are currently underway in my laboratory to dissect the brain pathways involved in this discovery and how the plant molecule acts to change the physiology in mice with the hope of discovering a clear target for appetite suppression. We have developed a number of unique neuronal cell models to study these pathways at the cellular level in tremendous detail not yet possible in the animal model. Our research to explore how we can prevent weight gain is an essential step for development of improved treatment options, and will lead to far-reaching and long-term cost benefits to the Canadian economy. Obesity is a major global health concern, especially in Western society where it is estimated that 30% of the population is obese and 65% is overweight. Visualizing the long-term impact of basic fundamental science ventures is forward-thinking and bold, but it is also imperative that we have a clear understanding of the biological foundations of physiology/health. The ability to move from bench to innovation has been the proven history of Dr. Belsham's program. Her ongoing research program will not only result in knowledge creation, but has the potential to advance neuroendocrine research, including transforming preventative treatment options for nutritionally-based neuronal disorders. By studying new fundamental mechanisms by which the brain controls appetite, there is hope for a supplement that can regulate appetite and weight gain.

一个复杂的神经系统已经进化到维持健康体重所需的能量平衡，但它在充足的时候偏向于体重增加。大脑是如何感知营养物质的还不清楚，但现在已经认识到大脑可以通过特定的神经元感知脂肪和碳水化合物，并可以通过调节大脑中神经肽的表达来调节进食。然而，到底是什么原因导致体重增加，通常是过量的脂肪和糖的摄入，是对抗肥胖的一个巨大问题。有趣的是，我们发现了一种植物来源的分子，可以减少小鼠的食物摄入量，即使它们正在食用高脂肪饮食。摄食量的减少持续数周，对雄性和雌性小鼠均有效。因此，我的实验室目前正在进行重大努力，以剖析与这一发现有关的大脑通路，以及植物分子如何改变小鼠的生理机能，希望找到抑制食欲的明确目标。我们已经开发了许多独特的神经元细胞模型，在细胞水平上研究这些通路，在动物模型中还不可能做到。我们的研究，以探讨如何防止体重增加是一个重要的一步，为发展改进的治疗方案，并将导致深远的和长期的成本效益，加拿大经济。肥胖是一个主要的全球健康问题，特别是在西方社会，估计30%的人口肥胖，65%超重。可视化基础科学风险的长期影响是前瞻性的和大胆的，但我们也必须清楚地了解生理学/健康的生物学基础。从实验室到创新的能力一直是贝尔舍姆博士项目的历史证明。她正在进行的研究计划不仅会产生知识创造，而且有可能推进神经内分泌研究，包括改变基于营养的神经元疾病的预防性治疗方案。通过研究大脑控制食欲的新的基本机制，有希望找到一种可以调节食欲和体重增加的补充剂。