Lab2Market - Investigating the potential appetite-supressing effects of a novel cytokinin.

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A complex neuronal system has evolved to maintain energy balance required for a healthy body weight, but it is biased towards weight gain in times of plenty. Exactly how the brain senses nutrients is not yet understood, but it is now recognized that the brain can sense fat and carbohydrates through specific neurons and can regulate feeding by modulating the expression of neuropeptides in the brain. However, what exactly causes weight gain, often by excess levels of fat and sugar intake, is a tremendous problem in the fight against obesity. Interestingly, we have discovered a plant-derived molecule that decreases food intake in mice, even when they were consuming a high fat diet. The decrease in food intake was sustained over weeks and was effective in both male and female mice. Therefore major efforts are currently underway in my laboratory to dissect the brain pathways involved in this discovery and how the plant molecule acts to change the physiology in mice with the hope of discovering a clear target for appetite suppression. We have developed a number of unique neuronal cell models to study these pathways at the cellular level in tremendous detail not yet possible in the animal model. Our research to explore how we can prevent weight gain is an essential step for development of improved treatment options, and will lead to far-reaching and long-term cost benefits to the Canadian economy. Obesity is a major global health concern, especially in Western society where it is estimated that 30% of the population is obese and 65% is overweight. Visualizing the long-term impact of basic fundamental science ventures is forward-thinking and bold, but it is also imperative that we have a clear understanding of the biological foundations of physiology/health. The ability to move from bench to innovation has been the proven history of Dr. Belsham's program. Her ongoing research program will not only result in knowledge creation, but has the potential to advance neuroendocrine research, including transforming preventative treatment options for nutritionally-based neuronal disorders. By studying new fundamental mechanisms by which the brain controls appetite, there is hope for a supplement that can regulate appetite and weight gain.