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Probing the role of mechanical rigidity in viral xrRNAs as the key to preventing their degradation by host RNases

Probing the role of mechanical rigidity in viral xrRNAs as the key to preventing their degradation by host RNases
探讨病毒 xrRNA 中机械刚性的作用,作为防止其被宿主 RNase 降解的关键
批准号:
462068
负责人:
Woodside Michael T
金额:
$68.55万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-03-01 至 2027-03-01

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中文摘要
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英文摘要
RNase enzymes are part of the cellular defenses against viral infection, digesting RNA from invading viruses. Some viruses evade RNases by partially blocking digestion so that the RNases produce viral RNA fragments, called xrRNAs, that interfere with cell
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Using engineered heterodimers to probe prion-like propagation of misfolding in SOD1
  • 批准号:
    469944
  • 项目类别:
    Operating Grants
  • 资助金额:
    $69.66万
  • 财政年份:
    2022
  • 负责人:
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  • 依托单位:
COVID-19 Variant Supplement - Targeting programmed ribosomal frameshifting as a therapeutic strategy against 2019-nCoV
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    443173
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  • 资助金额:
    $3.64万
  • 财政年份:
    2021
  • 负责人:
    Woodside Michael T
  • 依托单位:
Targeting programmed ribosomal frameshifting as a therapeutic strategy against 2019-nCoV
  • 批准号:
    422724
  • 项目类别:
    Operating Grants
  • 资助金额:
    $21.6万
  • 财政年份:
    2020
  • 负责人:
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  • 依托单位:
The role of mRNA conformational dynamics in stimulating translational recoding
  • 批准号:
    320554
  • 项目类别:
    Operating Grants
  • 资助金额:
    $53.99万
  • 财政年份:
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  • 负责人:
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  • 依托单位:
海外基金