Using engineered heterodimers to probe prion-like propagation of misfolding in SOD1

使用工程异二聚体探测 SOD1 中错误折叠的类朊病毒传播

• 批准号: 469944
• 负责人: Woodside Michael T
• 金额: $ 69.66万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-09-01 至 2027-09-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=469944&lang=en
• 关键词: Amyotrophic Lateral Sclerosis (Als); Enzymatic Activity; Fluorescence Spectroscopy And Microscopy Of Aggregation; Misfolding Inhibitors; Pathogenic Mutations; Prion-Like Conversion; Protein Misfolding; Sandwich Elisa; Single-Molecule Force Spectroscopy; S

Deposits of proteins that have formed incorrect ('misfolded') structures are a key feature in many neurodegenerative diseases (NDDs). Strikingly, these misfolded proteins can convert other, correctly folded molecules into the misfolded form and thereby pr

已经形成不正确（“错误折叠”）结构的蛋白质沉积是许多神经退行性疾病（NDD）的关键特征。引人注目的是，这些错误折叠的蛋白质可以将其他正确折叠的分子转化为错误折叠的形式，从而产生蛋白质。