Selective non-carbohydrate GBA2 inhibitors and their evaluation in models of Batten Disease.
Selective non-carbohydrate GBA2 inhibitors and their evaluation in models of Batten Disease.
批准号:
462565
负责人:
Vocadlo David
金额:
$33.16万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-03-01 至 2025-03-01
中文摘要
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英文摘要
Despite extensive efforts, there is only one clinically approved small molecule therapeutic that can slow the progression of any neurodegenerative disease. This compound is known as miglustat, and it is used to treat the rare orphan lysosomal disease know
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会议论文
Regulation of proteostasis by glycosylation of nucleocytoplasmic proteins.
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批准号:372076
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项目类别:Operating Grants
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资助金额:$57.96万
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财政年份:2017
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负责人:Vocadlo David
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依托单位:
Regulation of cellular proteostasis by glycosylation of nucleocytoplasmic proteins.
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批准号:351779
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项目类别:Operating Grants
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资助金额:$7.29万
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财政年份:2016
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负责人:Vocadlo David
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依托单位:
Glycosylation of hydroxymethylcytosine in mammalian genomes - distribution and functional roles.
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批准号:345292
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项目类别:Operating Grants
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资助金额:$54.3万
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财政年份:2016
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负责人:Vocadlo David
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依托单位:
CANADA RESEARCH CHAIRHOLDER - Tier 1 / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA - Niveau 1
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批准号:302751
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项目类别:
-
资助金额:$101.99万
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财政年份:2013
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负责人:Vocadlo David
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依托单位:
Generation of effective carbohydrate-based inhibitors of a glycosidase implicated in Alzheimer disease and their molecular mechanism of action.
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批准号:255267
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项目类别:Operating Grants
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资助金额:$38.51万
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财政年份:2012
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负责人:Vocadlo David
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依托单位:
海外基金