课题基金 / 基金详情

Generation of effective carbohydrate-based inhibitors of a glycosidase implicated in Alzheimer disease and their molecular mechanism of action.

Generation of effective carbohydrate-based inhibitors of a glycosidase implicated in Alzheimer disease and their molecular mechanism of action.
产生与阿尔茨海默病有关的有效的基于碳水化合物的糖苷酶抑制剂及其分子作用机制。
批准号：
255267
负责人：
Vocadlo David
金额：
$38.51万
依托单位：
Simon Fraser Health Unit (Burnaby)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2012
资助国家：
加拿大
项目状态：
已结题
起止时间：
2012-03-01 至 2016-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=255267&lang=en
关键词：
Chemical Synthesis Enzyme Inhibitor Inhibitor Design Neurodegeneration Pharmacokinetics Protein Glycosylation Tau

项目摘要

项目成果

Vocadlo David的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Alzheimer disease (AD) manifests both by the development of extracellular amyloid deposits (plaques) and intracellular aggregates known as neurofibrillary tangles (NFTs). The plaques result from accumulation of an insoluble peptide known as amyloid beta (
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Selective non-carbohydrate GBA2 inhibitors and their evaluation in models of Batten Disease.
Regulation of proteostasis by glycosylation of nucleocytoplasmic proteins.
Regulation of cellular proteostasis by glycosylation of nucleocytoplasmic proteins.
Glycosylation of hydroxymethylcytosine in mammalian genomes - distribution and functional roles.
海外基金