Investigating the outcomes of senescence on microglial physiological and immune functions: implications for viral infection and Alzheimer's disease pathology along the aging trajectory

研究衰老对小胶质细胞生理和免疫功能的影响：对病毒感染和阿尔茨海默病病理学沿衰老轨迹的影响

• 批准号: 464099
• 负责人: Tremblay Marie-Ève
• 金额: --
• 依托单位: University of Victoria (British Columbia)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-04-01 至 2026-04-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=464099&lang=en
• 关键词: Aging; Alzheimer; Imaging; Microglia; Molecular Analyses; Mouse; Senescence; Subtypes; Synapses; Viral Infection

Discoveries spanning the last decade have provided essential insights into Alzheimer's disease by identifying, as an important risk factor, immune challenges that affect microglia, the brain's immune cells. Microglia were recently shown to be a diverse ce

过去十年的发现通过确定影响大脑免疫细胞小胶质细胞的免疫挑战作为一个重要的风险因素，为阿尔茨海默病提供了重要的见解。小胶质细胞最近被证明是一种多样的细胞，