Role of short chain fatty acids in blood pressure regulation

我的研究计划的长期目标是了解血流和血压是如何调节的。体内的许多化学物质可以通过与细胞上的受体分子结合来改变血流和血压。最近有人提出，通常生活在我们肠道中的细菌产生的化学物质也可能作用于特定的受体，从而影响血液流动和压力。在这项研究中，我们将通过测量没有这些受体的小鼠的血流和压力来研究这种可能性。我们还将研究当我们给一些小鼠抗生素来杀死一些细菌时会发生什么，以及当我们给其他小鼠不同的饮食时会发生什么，这将改变细菌可以产生的化学物质的类型。总之，这些实验将告诉我们肠道细菌产生的化学物质是否在控制血液流动和压力方面发挥重要作用。同时，该计划将为研究生和本科生学员提供高质量的研究培训和专业发展机会。

The over-arching, long-term goal of my research program is to understand how blood flow and blood pressure are regulated. Lots of chemicals in the body can change blood flow and pressure by binding to molecules on cells called receptors. Recently it has been suggested that chemicals made by bacteria that normally live in our gut, may also be able to act on specific receptors and so may influence blood flow and pressure. In this study, we will investigate this possibility by making measurements of blood flow and pressure in mice that don't have these receptors. We will also look at what happens when we give some mice antibiotics to kill some of the bacteria, and when we will give other mice different diets which will change the types of chemicals that the bacteria can produce. Together, these experiments will tell us if the chemicals produced by gut bacteria have an important role controlling blood flow and pressure. At the same time, this planned program of will provide high quality research training and professional development opportunities for graduate and undergraduate trainees.