Interaction of ultrasound cavitation with membranes: Theoretical modelling and experimental characterization

超声空化与膜的相互作用：理论建模和实验表征

• 批准号: RGPIN-2020-04729
• 负责人: Karshafian, Raffi
• 金额: $ 2.04万
• 依托单位: Ryerson University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=740151
• 关键词: Interaction; ultrasound; cavitation; membranes; Theoretical

Cavitation is present in many physical phenomena and applications: Medical ultrasound imaging; disease targeted drug delivery; blood-brain-barrier opening; high intensity focused ultrasound; and sonothrombolysis. The application of ultrasound-microbubbles as a novel targeted drug delivery strategy has shown promising potential through enhanced permeability and endocytosis.  In our research program, we study the phenomenon of cavitation induced through ultrasonically-stimulated bubbles and their interaction with biological membranes such as cell membranes through theoretical and experimental approaches.

空化存在于许多物理现象和应用中：医学超声成像;疾病靶向药物递送;血脑屏障开放;高强度聚焦超声;和超声溶栓。超声微泡作为一种新型的靶向给药系统，通过增强药物的渗透性和内吞作用，显示出良好的应用前景。本课题从理论和实验两方面研究了超声微泡的空化效应及其与生物膜（如细胞膜）的相互作用。