Benchtop Walk-Up Time-of-Flight Mass Spectrometer

台式直接飞行时间质谱仪

• 批准号: RTI-2022-00055
• 负责人: Linington, Roger
• 金额: $ 10.65万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=741874
• 关键词: Benchtop; Walk; Up; Time; Flight

Mass spectrometry is an essential analytical technique in modern chemistry research. Over the past two decades developments in both hardware and data processing software have transformed this technique and its use in laboratory research. From a situation in the 1990's where mass spectrometry was the exclusive domain of specialists, we are now in a situation where mass spectrometers are routinely present in research facilities engaged in all aspects of chemistry. However, to date these open access instruments have been able to obtain only 'low-resolution' mass spectral data with accuracy up to one decimal place. This limits our ability to characterize the structures of molecules synthesized in the laboratory, and prevents researchers from employing many of the latest compound annotation tools, which require high accuracy mass spectral data. This proposal supports the purchase of a new benchtop 'high-resolution' mass spectrometry instrument that combines robust hardware design suitable for general laboratory use with accurate mass measurements up to four decimal places. This new instrument provides bench researchers with real-time access to high-resolution mass spectral data that will have a fundamental impact on the ways in which new research projects are performed, opening up new avenues for compound characterization and discovery in both basic and applied research areas.

质谱学是现代化学研究中必不可少的分析技术。在过去的二十年里，硬件和数据处理软件的发展改变了这项技术及其在实验室研究中的使用。从20世纪90年代的S时代，质谱学是专家的专属领域，我们现在的情况是，质谱仪经常出现在从事化学各个方面的研究设施中。然而，到目前为止，这些开放获取的仪器只能获得精度高达一位小数点的“低分辨率”质量光谱数据。这限制了我们表征实验室合成的分子结构的能力，并阻止研究人员使用许多最新的化合物注释工具，这些工具需要高精度的质谱学数据。这项建议支持购买一种新的台式高分辨率质谱仪，该仪器结合了适合一般实验室使用的坚固的硬件设计，以及高达四位小数位的准确质量测量。这一新仪器为实验室研究人员提供了实时访问高分辨率质谱学数据的机会，这些数据将对新研究项目的执行方式产生根本性影响，为基础和应用研究领域的化合物表征和发现开辟了新的途径。