Chemical Biology - High-Throughput Screening

化学生物学 - 高通量筛选

• 批准号: 1000230755-2014
• 负责人: Linington, Roger
• 金额: $ 8.74万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693118
• 关键词: Chemical; Biology; Throughput; Screening

Environmental bacteria produce a vast array of natural compounds for defense, communication, and the acquisition of nutrients. Many of these compounds have antibiotic and anti-cancer properties, and some have formed the basis for the development of clinically used drugs. My laboratory studies natural products chemistry, and specializes in the detailed biological and chemical characterization of compounds derived from environmental microorganisms. Through a combination of high-content screening, ultra-high sensitivity analytical chemistry, and genomics and informatics, we are building a picture of the metabolic capacity of these environmental strains, and discovering new human health applications for many of these unique compounds.

环境细菌产生大量的天然化合物，用于防御，通信和获取营养。这些化合物中的许多具有抗生素和抗癌特性，并且一些已经形成了临床使用药物的开发基础。我的实验室研究天然产物化学，专门研究来自环境微生物的化合物的详细生物和化学表征。通过高含量筛选，超高灵敏度分析化学，基因组学和信息学的结合，我们正在构建这些环境菌株的代谢能力，并为许多这些独特的化合物发现新的人类健康应用。