Chemical Biology - High-Throughput Screening

环境细菌产生大量的天然化合物，用于防御、交流和获取营养。这些化合物中有许多具有抗生素和抗癌特性，其中一些已成为临床使用药物开发的基础。我的实验室研究天然产物化学，专门研究源自环境微生物的化合物的详细生物学和化学特性。通过高含量筛选、超高灵敏度分析化学、基因组学和信息学的结合，我们正在构建这些环境菌株代谢能力的图谱，并发现许多这些独特化合物在人类健康方面的新应用。

Environmental bacteria produce a vast array of natural compounds for defense, communication, and the acquisition of nutrients. Many of these compounds have antibiotic and anti-cancer properties, and some have formed the basis for the development of clinically used drugs. My laboratory studies natural products chemistry, and specializes in the detailed biological and chemical characterization of compounds derived from environmental microorganisms. Through a combination of high-content screening, ultra-high sensitivity analytical chemistry, and genomics and informatics, we are building a picture of the metabolic capacity of these environmental strains, and discovering new human health applications for many of these unique compounds.