Design, Synthesis and Evaluation of Functional Benzosiloles and New Reactions of Strained Carbocycles

功能性苯并硅杂环化合物和应变碳环新反应的设计、合成和评价

• 批准号: RGPIN-2021-03925
• 负责人: Pagenkopf, Brian
• 金额: $ 1.75万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=742775
• 关键词: Design; Synthesis; Evaluation; Functional; Benzosiloles

We are a synthetic organic chemistry laboratory and are internationally recognized experts in the art of manipulating carbon-containing molecules. We develop new chemical reactions and strategically transform molecules with certain characteristics into new molecules with different properties. 1. Synthesis of Novel Benzosilole Chromophores. Fluorescent chromophores are molecules that glow or give off light when irradiated with invisible ultraviolet (or "black") light. They are critical for many technologies in everyday life, including electronics, medical diagnostics, and even laundry detergents that bring extra whiteness to T-shirts. We use advanced organic chemistry to prepare novel benzosilole chromophores that contain silicon atoms with exciting new properties for commercial applications. Our experience with investigating structure-activity relationships (SARs) of drugs influences our synthetic planning in the systematic optimization of chromophores. 2. Reactions of Strained Donor-acceptor Carbocyles. A carbon atom is generally in one of three configurations when bonded. We make small rings with just three or four carbon atoms, in which the distorted bond angle increases strain and facilitates ring opening, and we then intercept the breakage with complementary molecules to create new chemical entities. We combine molecules in novel ways and reveal new synthetic methods, which are the cornerstone of drug discovery, pharmaceuticals, and specialty chemicals. EDI and HQP Training. My carefully crafted HQP training strategy revolves around the framework of synthetic organic chemistry. All HQP are expected to respect a fair and inclusive work environment, participate in activities that foster professional growth, and fully support the learning and engagement of others within the group and in the broader community. My HQP acquire technical skills in synthetic chemistry and translational skills in: writing, data and time management, teamwork, public speaking, etc. The advanced chemistry skills that I foster in my HQP build upon understanding the broadest aspects of synthetic organic chemistry, which not only make them particularly desired by employers in pharmaceutical and related chemical manufacturing industries, but also provide them with a valuable transferable skill set in the age of silo education. My HQP have published important research results, earned awards and scholarships, and secured positions in academia, research labs, and pharmaceutical industries. Impact. The research produced by my diverse group of HQP benefits society in the long term by helping develop new chemical entities and processes, and these contributions will make medications more easily accessible and more economical to manufacture. We are also at the forefront of creating novel materials to open doors to and pave the way for projected high-tech applications towards a green economy.

我们是一个合成有机化学实验室，是国际公认的操纵含碳分子艺术的专家。我们开发新的化学反应，战略性地将具有某种特性的分子转化为具有不同性质的新分子。1. 新型苯并硅酮发色团的合成。荧光发色团是在不可见的紫外线（或“黑色”）光照射下发光或发光的分子。它们对日常生活中的许多技术都至关重要，包括电子产品、医疗诊断，甚至是能给t恤带来额外白度的洗衣剂。我们利用先进的有机化学技术制备了含有硅原子的新型苯并硅酮发色团，具有令人兴奋的新特性，可用于商业应用。我们在研究药物结构-活性关系（SARs）方面的经验影响了我们在系统优化发色团方面的合成计划。2. 张力供体-受体碳环的反应。碳原子成键时通常是三种构型中的一种。我们制造了只有三到四个碳原子的小环，其中扭曲的键角增加了张力，促进了环的打开，然后我们用互补分子拦截断裂，以创造新的化学实体。我们以新颖的方式结合分子并揭示新的合成方法，这是药物发现，制药和特种化学品的基石。EDI和HQP培训。我精心设计的HQP培训策略围绕着合成有机化学的框架展开。所有HQP都应该尊重一个公平和包容的工作环境，参与促进专业成长的活动，并充分支持团队和更广泛社区内其他人的学习和参与。我的HQP具备了合成化学的技术技能和翻译技能：写作、数据和时间管理、团队合作、公开演讲等。我在HQP中培养的先进化学技能建立在对合成有机化学最广泛方面的理解之上，这不仅使他们成为制药和相关化学制造行业的雇主特别需要的，而且还为他们提供了在筒仓教育时代有价值的可转移技能。我的HQP发表了重要的研究成果，获得了奖项和奖学金，并在学术界、研究实验室和制药行业获得了职位。的影响。我的不同HQP小组所做的研究，通过帮助开发新的化学实体和工艺，从长远来看有利于社会，这些贡献将使药物更容易获得，更经济地制造。我们也走在创造新材料的前沿，为绿色经济的高科技应用打开大门并铺平道路。