Focused High/Low Intensity Ultrasound System for Minimally Invasive Inside Body Bio Printing and Drug Delivery

用于微创体内生物打印和药物输送的聚焦高/低强度超声系统

• 批准号: RTI-2022-00615
• 负责人: Packirisamy, Muthukumaran
• 金额: $ 10.93万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=742980
• 关键词: Focused; Low; Intensity; Ultrasound; System

Even though Concordia University houses various state-of-the-art research facilities, a number of crucial studies initiated and patented from our lab in the areas of inside body bio printing, noninvasive cell stimulation and drug delivery using ultrasound waves are currently limited due to the dire need for a highly specialized ultrasound beam steering and focusing. Such equipment would enhance ongoing research on developing cutting edge technologies in the area of remote tissue printing and noninvasive nano particle synthesis and drug delivery. The supported research programs includes but limited to: 1)Micro particle and cell manipulation/stimulation, 2) Selective nano particle synthesis, 3) Micro particle and cell streaming control and 4) In-situ/in-vitro bio printing and drug delivery. The Phased Array High Intensity Focused Ultrasound Transducer from Sonicconcepts enables our research group to conduct research on the mentioned programs. Having 128 piezo actuator provides a wide range of ultrasound beam steering and focusing capabilities. No similar equipment is available at Concordia or known partner institutions. Acquiring this equipment would not only advance effective collaboration between engineers, biologists and physicists for future convergence but would also sustain leading-edge research success, strengthen training goals, enhance quality of dissertations, and shorten graduation time. We currently have 25 graduate students and 5 postdocs working on the mentioned research programs. They have mastered the theory and conducted multiphysics simulations related to the ultrasound wave patterning. In addition to conducting cutting edge research, the equipment enables them to validate their modeling and simulations. In addition, we believe that the collaboration of these 8 labs in multidisciplinary research and development around this equipment will lead to practical products that has huge market and a few spin-off can be resulted from universities. The collaborations between research labs around this equipment with diverse expertise, acoustic, micro/nano elector mechanical systems and head and neck cancer treatment, will manifest themselves and converge in the proposed multidisciplinary research programs. This essential research is complementary to both our engineers, physicists and physicians working in the area of microsystems, microfluidics, application of micro-nano integrated systems for bio and chemical applications and cancer treatment and tissue printing. The proposed research programs introduces new trend in bioprinting. However, the incapability of controlling the ultrasonic field electronically is a major setback. The requested equipment surmounts this obstacle by permitting electronic steering and focusing of high intensity ultrasound. Housed in the Optical-bio Microsystems Lab, the system will be open to on-site and other inter-institutional collaborations across Canada including McGill, UdeM, ETS and École Polytechnique.

即使Concordia University设有各种最先进的研究设施，但目前，由于对高度专业的超声波转向和聚焦和聚焦和焦点的迫切需求，目前使用超声波的无创刺激和药物递送的内部生物印刷刺激和药物递送的领域，从我们的实验室中启动并获得了许多关键研究。此类设备将增强有关在远程组织印刷和无创纳米颗粒合成和药物递送领域开发尖端技术的持续研究。受支持的研究计划包括但限制为：1）微粒和细胞操作/刺激，2）选择性纳米颗粒合成，3）微粒和细胞流控制和4）原位/原位/体外生物印刷和药物递送。来自SonicConcepts的分阶段阵列高强度集中的超声传感器使我们的研究小组能够对上述程序进行研究。具有128个压电执行器可提供广泛的超声梁转向和聚焦功能。 Concordia或已知合作伙伴机构没有类似的设备。获取该设备不仅会提高工程师，生物学家和物理学家之间的有效合作，以促进未来的融合，而且还将维持领先的研究成功，增强培训目标，提高论文的质量以及缩短毕业时间。目前，我们有25名研究生和5个专业的博士生在上述研究计划上。他们掌握了该理论，并进行了与超声波图案相关的多物理模拟。除了进行尖端研究外，设备还可以验证其建模和模拟。此外，我们认为，这8个实验室在该设备周围的多学科研究和开发中的合作将导致实用产品具有巨大的市场，并且可以由大学造成一些衍生产品。研究实验室围绕该设备的研究实验室与潜水专业知识，声学，微/纳米选举机械系统以及头颈癌的治疗之间的合作将在拟议的多学科研究计划中表现出来。这项基本研究对于在微系统，微流体学领域工作，微纳米集成系统在生物和化学应用以及癌症治疗以及癌症治疗以及组织印刷方面的应用以及在微型系统领域的工作都是完整的。拟议的研究计划介绍了生物打印的新趋势。但是，以电子方式控制超声波场的无能是主要的挫折。所需的设备通过允许电子转向和高强度超声检查来克服这一障碍。该系统位于光学生物生物系统实验室中，该系统将开放到加拿大各地的现场和其他机构间合作，包括McGill，UDEM，ETS，ETS和Ecole Polytechnique。