Microphotonics and Nano Integrated Bio Microsystems and Applications

微光子学和纳米集成生物微系统及应用

• 批准号: RGPIN-2014-03821
• 负责人: Packirisamy, Muthukumaran
• 金额: $ 3.64万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=661383
• 关键词: Microphotonics; Nano; Integrated; Bio; Microsystems

There is always an ever growing demand for miniaturized devices called Lab on Chips (LOC) that can do multiple functions such as sample handling, sample preparation and diagnosis, in a more efficient and economical way. In addition, these LOCs are expected to be sensitive, fast responsive, bio compatible, disposable and portable. Hence, this proposal aims to develop technologies and methods that will enable realization of such devices, through systematic research supported by analytical and experimental methodologies followed by device development. The critical requirements of being highly sensitive and quickly responsive will be addressed by developing integrated microsystems.**Integrated microsystems provide an answer to the problem of rapid pathogenic detection by integrating photonics and nano features. However, there are some critical issues associated with biophotonics, such as miniaturization and portability. The portability of the device is required for in-situ medical detections, while miniaturization is essential for handling smaller sample volumes in order to achieve high throughput. Another bottleneck is the integration of nano features with microdevices in order to enhance the performance. These conditions cannot be satisfied unless a technology to integrate microsystems with microphotonics and nano features is developed. Hence, this grant proposes to develop the field of microphotonics and nano integrated Bio Microsystems which will have vast potential for drug delivery, medical diagnosis, lab-on-a-chip, biodefense, biosensors, point-of-care diagnostic applications, therapeutic micro/nano technologies, microarrays and biochips, bioassays, etc. that would be of great benefit to our society. **On considering the above possibilities, one could anticipate that there will be a great demand for sensors and other devices in high volume at low cost with multi-domain needs. This also makes the present proposal of developing integrated microsystems on silicon and polymer platforms highly relevant. The objective of realizing low cost, efficient and reliable integrated microsystems for various applications through this grant will definitely enhance knowledge in many multi-disciplinary areas such as microfabrication, microphotonics, optical microsystems, micromechanics, bio sensing, microfluidics, etc.**The understanding of influence of material and optical properties in relation to process and design limitations is fundamentally critical to the realization of micro-nano integrated devices for biological, cellular and chemical studies. This proposal will also provide opportunities to do research in multi-disciplinary areas involving engineers, physicists and biologists. The proposed research will also open possibilities for cell sorting, cell trapping, micromechanical and optical cellular studies.**In addition to the creation of research knowledge on various aspects such microphotonics, nano integration, bio-optical integration and suspended microfluidics, process development required for microphotonic elements, in-situ and ex-situ nanosynthesis, micro-nano integration, and Bio Mcrosystems by combining biological and engineering expertise, this research will attract strong interest from industries. **In summary, the development of integrated microsystems that covers a wide spectrum of applications including, aerospace, space, communication, biology, medicine, security, etc., will definitely sophisticate the quality of Canadian life in every possible way, increase the global competitiveness in the product differentiating micro and nano technologies, create new products and possibilities for venture development, and finally increase the economic activities of Canada, through innovation, HQP training and industrial collaboration.

人们对称为芯片实验室（Lab on Chips，简称LAB）的小型化设备的需求一直在不断增长，这些设备可以以更有效和更经济的方式完成多种功能，如样品处理、样品制备和诊断。此外，这些LOC预期是敏感的、快速响应的、生物相容的、一次性的和便携的。因此，本提案旨在开发技术和方法，通过分析和实验方法支持的系统研究，然后进行设备开发，从而实现这种设备。 高度敏感和快速反应的关键要求将通过开发集成微系统来解决。集成微系统通过集成光子学和纳米特征为快速病原体检测问题提供了答案。然而，有一些关键问题与生物光子学，如小型化和便携性。该设备的便携性是需要在现场医疗检测，而小型化是必不可少的处理较小的样品体积，以实现高通量。另一个瓶颈是纳米特征与微器件的集成，以提高性能。这些条件不能得到满足，除非开发出一种将微系统与微光子学和纳米特征相结合的技术。因此，该补助金建议开发微光子学和纳米集成生物微系统领域，这些领域将在药物输送，医疗诊断，芯片实验室，生物防御，生物传感器，即时诊断应用，治疗微/纳米技术，微阵列和生物芯片，生物测定等方面具有巨大潜力，这将对我们的社会大有裨益。** 考虑到上述可能性，可以预期，对于具有多领域需求的低成本高容量传感器和其他设备的需求将很大。这也使得目前提出的在硅和聚合物平台上开发集成微系统的建议具有高度相关性。通过这项资助，实现低成本，高效和可靠的集成微系统的目标将肯定会提高许多多学科领域的知识，如微制造，微光子学，光学微系统，微力学，生物传感，微流体等。理解材料和光学性质对工艺和设计限制的影响对于实现用于生物、细胞和化学研究的微纳集成器件至关重要。这项提案还将提供机会，在涉及工程师，物理学家和生物学家的多学科领域进行研究。拟议的研究还将为细胞分选，细胞捕获，微机械和光学细胞研究开辟可能性。除了通过结合生物学和工程专业知识创建微光子学，纳米集成，生物光学集成和悬浮微流体，微光子元件，原位和非原位纳米合成，微纳米集成和生物微系统所需的工艺开发等各个方面的研究知识外，这项研究将吸引行业的浓厚兴趣。 ** 总之，集成微系统的开发涵盖了广泛的应用，包括航空航天，空间，通信，生物学，医学，安全等，通过创新、HQP培训和工业合作，我们将以各种可能的方式提高加拿大的生活质量，提高产品差异化微纳米技术的全球竞争力，创造新产品和风险开发的可能性，最终增加加拿大的经济活动。