Microphotonics and Nano Integrated Bio Microsystems and Applications

对称为芯片实验室(LOC)的小型化设备的需求一直在不断增长，这种设备可以以更高效、更经济的方式完成多种功能，如样品处理、样品制备和诊断。此外，这些LOC有望是敏感的、快速响应的、生物兼容的、一次性的和便携的。因此，本提案旨在通过分析和实验方法支持的系统研究以及设备开发，开发能够实现这类设备的技术和方法。高灵敏度和快速反应的关键要求将通过开发集成微系统来解决。**集成微系统通过集成光子学和纳米特征为快速病原体检测提供了解决方案。然而，与生物光子学相关的一些关键问题，如小型化和便携性。现场医学检测需要设备的便携性，而为了实现高吞吐量，小型化对于处理较小的样品体积是必不可少的。另一个瓶颈是纳米特征与微器件的集成，以提高性能。除非开发出一种将微系统与微光子学和纳米特性相结合的技术，否则这些条件是不可能满足的。因此，这笔拨款建议发展微光子学和纳米集成生物微系统领域，这些领域将在药物递送、医疗诊断、芯片实验室、生物防御、生物传感器、护理点诊断应用、治疗性微/纳米技术、微阵列和生物芯片、生物检测等方面具有巨大潜力，将对我们的社会产生重大好处。**考虑到上述可能性，人们可以预见，对传感器和其他设备的高容量、低成本和多域需求的需求将会很大。这也使得目前提出的在硅和聚合物平台上开发集成微系统的建议具有很高的相关性。通过这笔赠款为各种应用实现低成本、高效率和可靠的集成微系统的目标肯定会增强许多多学科领域的知识，如微制造、微光子学、光学微系统、微机械、生物传感、微流体学等。**了解材料和光学性能对工艺和设计限制的影响对于实现用于生物、细胞和化学研究的微纳米集成设备至关重要。这项提议还将提供在涉及工程师、物理学家和生物学家的多学科领域进行研究的机会。拟议中的研究还将为细胞分类、细胞捕获、微机械和光学细胞研究提供可能性。**除了创造微光子学、纳米集成、生物光学集成和悬浮微流体、微光子元件所需的工艺开发、原位和非原位纳米合成、微纳米集成以及生物微系统等多方面的研究知识外，这项研究还将吸引业界的强烈兴趣。*总而言之，涵盖航空航天、空间、通信、生物、医学、安全等广泛应用的集成微系统的开发，肯定会以各种可能的方式提高加拿大的生活质量，增加微纳米技术差异化产品的全球竞争力，创造新产品和创业发展的可能性，并最终通过创新、HQP培训和产业合作增加加拿大的经济活动。

There is always an ever growing demand for miniaturized devices called Lab on Chips (LOC) that can do multiple functions such as sample handling, sample preparation and diagnosis, in a more efficient and economical way. In addition, these LOCs are expected to be sensitive, fast responsive, bio compatible, disposable and portable. Hence, this proposal aims to develop technologies and methods that will enable realization of such devices, through systematic research supported by analytical and experimental methodologies followed by device development. The critical requirements of being highly sensitive and quickly responsive will be addressed by developing integrated microsystems.**Integrated microsystems provide an answer to the problem of rapid pathogenic detection by integrating photonics and nano features. However, there are some critical issues associated with biophotonics, such as miniaturization and portability. The portability of the device is required for in-situ medical detections, while miniaturization is essential for handling smaller sample volumes in order to achieve high throughput. Another bottleneck is the integration of nano features with microdevices in order to enhance the performance. These conditions cannot be satisfied unless a technology to integrate microsystems with microphotonics and nano features is developed. Hence, this grant proposes to develop the field of microphotonics and nano integrated Bio Microsystems which will have vast potential for drug delivery, medical diagnosis, lab-on-a-chip, biodefense, biosensors, point-of-care diagnostic applications, therapeutic micro/nano technologies, microarrays and biochips, bioassays, etc. that would be of great benefit to our society. **On considering the above possibilities, one could anticipate that there will be a great demand for sensors and other devices in high volume at low cost with multi-domain needs. This also makes the present proposal of developing integrated microsystems on silicon and polymer platforms highly relevant. The objective of realizing low cost, efficient and reliable integrated microsystems for various applications through this grant will definitely enhance knowledge in many multi-disciplinary areas such as microfabrication, microphotonics, optical microsystems, micromechanics, bio sensing, microfluidics, etc.**The understanding of influence of material and optical properties in relation to process and design limitations is fundamentally critical to the realization of micro-nano integrated devices for biological, cellular and chemical studies. This proposal will also provide opportunities to do research in multi-disciplinary areas involving engineers, physicists and biologists. The proposed research will also open possibilities for cell sorting, cell trapping, micromechanical and optical cellular studies.**In addition to the creation of research knowledge on various aspects such microphotonics, nano integration, bio-optical integration and suspended microfluidics, process development required for microphotonic elements, in-situ and ex-situ nanosynthesis, micro-nano integration, and Bio Mcrosystems by combining biological and engineering expertise, this research will attract strong interest from industries. **In summary, the development of integrated microsystems that covers a wide spectrum of applications including, aerospace, space, communication, biology, medicine, security, etc., will definitely sophisticate the quality of Canadian life in every possible way, increase the global competitiveness in the product differentiating micro and nano technologies, create new products and possibilities for venture development, and finally increase the economic activities of Canada, through innovation, HQP training and industrial collaboration.