Automated high resolution morphological and behavioural analysis system

一个多学科研究小组，在研究斑马鱼的发育、神经科学生理学、毒理学、药理学、病毒学和行为方面具有专门知识，正在申请资金购买自动高分辨率视频跟踪和分析系统。具体而言，所要求的最先进的视频跟踪系统（Ramona MCAM）将用于以高分辨率和高通量评估斑马鱼的形态和行为。这种创新的系统将能够快速，无偏，高通量，准确和一致的视频辅助测量范围广泛的形态和行为参数，以解决神经生物学，动物生理学，毒理学，药理学和病毒学的基础和应用问题。具体而言，所要求的设备将允许申请人及其团队：1）研究斑马鱼神经元发育的分子机制，2）研究病毒感染，生物材料和内分泌干扰物对斑马鱼幼虫发育，神经发育，生理学和行为的影响。我们的HQP将为他们各自的研究领域以及高分辨率成像和复杂行为数据分析所需的尖端培训提供宝贵的机会。它们将受到学术界，政府或行业研究部门的高度追捧，因为使用斑马鱼的研究对于疾病的生物医学建模，药物筛选和毒理学研究变得更加重要。

A multidisciplinary team of researchers with expertise in studying development, neurosciences physiology, toxicology, pharmacology, virology and behaviour in zebrafish is requesting funds for the purchase of an automated high-resolution video tracking and analysis system. Specifically, the requested state-of-the-art video-tracking system (Ramona MCAM) will be used to evaluate zebrafish morphology and behaviour at high resolution and high throughput. This innovative system will enable fast, unbiased, high throughput, accurate, and consistent video-aided measurements of a broad range of morphological and behavioural parameters to address both fundamental and applied questions in neurobiology, animal physiology, toxicology, pharmacology and virology. Specifically, the requested equipment will allow the applicants and their team to: 1) investigate molecular mechanisms in neuronal development in zebrafish and 2) investigate the effects of virus infection, biomaterials and endocrine disruptors on the development, neurodevelopment, physiology and behaviour of zebrafish larvae. Our HQP will be provided with an invaluable opportunity for the cutting-edge training needed for their respective research areas as well as in high-resolution imaging and complex behavioural data analysis. They will be highly sought after by academia, government, or industry research departments as research using zebrafish becomes more significant for biomedical modelling of disease, drug screening, and toxicological studies.