Cardiovascular suite for the imposition and assessment of physiological stressors

用于施加和评估生理应激源的心血管套件

• 批准号: RTI-2023-00062
• 负责人: Burr, Jamie
• 金额: $ 10.15万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744491
• 关键词: Cardiovascular; suite; imposition; assessment; physiological

Exercise is a common physiological stressor that affects multiple organ systems, providing a valuable model to study cardiovascular and other responses involved in homeostasis and adaptation in humans. Importantly, the ability of the heart to effectively pump blood can also be affected by other common stressors (e.g., heat, altitude, cannabis use) that can interact with the stresses imposed by exercise. Measuring cardiac output under these conditions is thus incredibly important for understanding normal exercise physiology and its applications to improving human life- from clinical applications to sport performance and military activities to space travel. However, measurements of cardiac output can be difficult to perform during intense exercise using standard imaging practices, and clinical alternatives are highly invasive or prohibitively expensive. This grant requests funds to purchase an inert gas rebreathe system to non-invasively measure cardiac output at rest and during exercise, and an environmental exercise chamber to study the effects of thermal and hypoxic stress and cannabis use on cardiovascular function during exercise. This equipment represents industry leading technologies that will fulfill a critical and urgent need in the applicants' research programs for 1) accurate and reliable measurements of cardiac output during exercise, and 2) examining the additional effects of common environmental stressors on cardiac output during exercise. Access to this equipment will support leading-edge NSERC-funded research and training programs at both U Guelph and McMaster. Dr. Burr's lab requires the equipment to follow-up on novel findings that blood flow restriction to the legs during exercise causes unexpected, and yet unexplained, augmentation of the ability to take up and use oxygen to perform muscular work. It will also advance research that shows sport- and environment-specific cardiac adaptations to exercise. Dr. Millar's group requires the inert gas rebreathing system to expand on important work understanding the sex differences in blood pressure response during exercise, and how blood pressure is modulated by differences in sympathetic control of vascular and cardiac output through differing intensities of exercise. The inert gas rebreathing system is also crucial to Dr. Gibala's work understanding how various exposures to exercise alter cardiac output, blood, and oxygen delivery to skeletal muscle. Finally, Drs Burr and Millar require both the enclosed chamber and the inert gas rebreathing device to support their pioneering and timely work examining the effects of cannabis on cardiovascular function during exercise. The applicants train a diverse group of 28 HQP who are currently hindered by a lack of access to this equipment. The requested items will greatly expand our research capacity and, including additional users, could positively benefit >50 HQP while supporting collaborative research across institutions.

运动是一种常见的生理应激源，影响多个器官系统，提供了一个有价值的模型来研究心血管和其他反应参与人体内稳态和适应。重要的是，心脏有效泵血的能力也会受到其他常见应激源的影响（例如，热、海拔、大麻使用），这些因素可以与运动施加的压力相互作用。因此，在这些条件下测量心输出量对于理解正常运动生理学及其在改善人类生活中的应用（从临床应用到运动表现和军事活动到太空旅行）非常重要。然而，使用标准成像实践在剧烈运动期间可能难以执行心输出量的测量，并且临床替代方案是高度侵入性的或昂贵得令人望而却步。该赠款要求资金购买惰性气体再呼吸系统，以非侵入性方式测量静息和运动期间的心输出量，以及环境运动室，以研究热和缺氧应激以及大麻使用对运动期间心血管功能的影响。该设备代表了行业领先的技术，将满足申请人研究项目中的关键和迫切需求，即1）运动期间心输出量的准确和可靠测量，以及2）检查常见环境应激源对运动期间心输出量的额外影响。获得这些设备将支持领先的NSERC资助的研究和培训计划在U圭尔夫和麦克马斯特。Burr博士的实验室需要这些设备来跟踪新的发现，即运动期间腿部的血流限制会导致意外的，但无法解释的，摄取和使用氧气进行肌肉工作的能力增强。它还将推进研究，显示运动和环境特定的心脏适应运动。Millar博士的小组需要惰性气体再呼吸系统来扩展重要的工作，了解运动期间血压反应的性别差异，以及血压如何通过不同强度的运动调节血管和心输出量的交感神经控制差异。惰性气体再呼吸系统对于Gibala博士的工作也至关重要，他了解了各种运动暴露如何改变心脏输出量，血液和骨骼肌的氧气输送。最后，Burr和Millar博士需要封闭室和惰性气体再呼吸装置来支持他们的开创性和及时的工作，检查大麻对运动期间心血管功能的影响。 申请人培训了一个由28名HQP组成的多样化小组，他们目前因无法获得这种设备而受到阻碍。所要求的项目将大大扩大我们的研究能力，包括额外的用户，可以积极受益于>50 HQP，同时支持跨机构的合作研究。