Molecular Regulation of Auxin Signaling in Plant Development

植物发育中生长素信号传导的分子调控

• 批准号: RGPIN-2017-06584
• 负责人: Crosby, William
• 金额: $ 1.82万
• 依托单位: University of Windsor
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744718
• 关键词: Molecular; Regulation; Auxin; Signaling; Plant

Summary of the ProposalProteins are complex molecules that carry out a variety of important cellular functions that range from structure determination to the regulation of the cell's chemistry. It follows that the number of different types and amounts of proteins present in a cell at any given time are critical to defining the function of that cell - including their contribution to the tissues and organs that make up the 'body plan' of the organism of which they are a part. Proteins are coded or expressed' by genes as the dictionary' of life, and it is at the point of gene expression and protein synthesis that the cell can regulate expression of the many thousands of proteins that exist at any given time. But this complex repertoire of cellular proteins can also be regulated after they are synthesized - by a process of selected protein destruction as one aspect of the ability of cells to regulate their complement of proteins. Nowhere is this more evident than in plants, where the targeted protein degradation machinery is about 10x more complex than in humans. In this proposal, we seek to better understand the underlying mechanisms by which targeted protein destruction is regulated in plants. This foundational knowledge will have far-reaching impacts on our understanding of how plants develop and how they adapt to environmental challenges such as drought stress, cold adaptation and global warming.

蛋白质是一种复杂的分子，具有多种重要的细胞功能，从结构决定到细胞化学的调节。因此，在任何给定时间存在于细胞中的不同类型和数量的蛋白质的数量对于定义该细胞的功能至关重要-包括它们对组成生物体“身体计划”的组织和器官的贡献。蛋白质是由“作为生命字典的基因”编码或表达的，正是在基因表达和蛋白质合成的时候，细胞可以调节在任何给定时间存在的数千种蛋白质的表达。但是，这种复杂的细胞蛋白质库也可以在合成后进行调节-通过选择蛋白质破坏的过程，作为细胞调节其蛋白质补体能力的一个方面。这一点在植物中表现得最为明显，植物中的靶蛋白降解机制比人类复杂10倍。在这项提案中，我们试图更好地了解植物中靶向蛋白质破坏的潜在机制。这些基础知识将对我们理解植物如何发育以及它们如何适应干旱胁迫，寒冷适应和全球变暖等环境挑战产生深远的影响。