Examination of the Factors Influencing Boron-Mediated Cleavage of Inert C-O Bonds

影响硼介导的惰性 C-O 键断裂的因素的研究

• 批准号: 579994-2022
• 负责人: Davis, RebeccaRL
• 金额: $ 1.82万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747365
• 关键词: Examination; Factors; Influencing; Boron; Mediated

Selective cleavage of C-O bonds is an ongoing challenge in the field of organic chemistry and is an area of great interest as C-O bonds are found in many naturally occurring compounds and materials. The selective cleavage of this linkage holds promise as a way of generating useful small molecule feedstocks from complex polymers. Recent work by our collaborators in the Williams lab has demonstrated the potential power of mixtures of boron trihalides in mediating selective C-O bond cleavage. The proposed research collaboration will combine the experimental and computational strengths of the Williams and Davis research groups to provide the first general model of reactivity and selectivity for boron mediated C-O bond cleavage. The reaction design techniques employed by each group will be combined for the first time to train students in state-of the-art reaction development and mechanistic techniques while also serving as proof of principle for the power of combining these methods in advancing the rate of reaction development. The information gained from this work will then be leveraged to design new boron Lewis acids which can be applied to the breakdown and recycling of epoxy plastics. This will combat the negative environmental impacts of petroleum-based epoxy resins by developing a sustainable and renewable source of epoxy resins. The knowledge gained from this work and the boron species developed will help to address the growing global issue of plastic pollution.

C-O键的选择性断裂是有机化学领域中的持续挑战，并且是非常感兴趣的领域，因为在许多天然存在的化合物和材料中发现了C-O键。该键的选择性裂解有望作为从复杂聚合物产生有用的小分子原料的方式。我们在威廉姆斯实验室的合作者最近的工作已经证明了三卤化硼混合物在介导选择性C-O键断裂中的潜在能力。拟议的研究合作将联合收割机的实验和计算实力的威廉姆斯和戴维斯研究小组提供的第一个一般模型的反应性和选择性硼介导的C-O键裂解。每个小组采用的反应设计技术将首次结合起来，以培养学生最先进的反应开发和机械技术，同时也作为结合这些方法提高反应开发速度的力量的原则证明。从这项工作中获得的信息将被用来设计新的硼刘易斯酸，可应用于环氧塑料的分解和回收。这将通过开发一种可持续和可再生的环氧树脂来源来对抗石油基环氧树脂对环境的负面影响。从这项工作中获得的知识和开发的硼物种将有助于解决日益严重的全球塑料污染问题。