Superhydrophobic and icephobic materials for biomedical engineering applications

用于生物医学工程应用的超疏水和疏冰材料

• 批准号: 580586-2022
• 负责人: Yu, HoganHZ
• 金额: $ 1.82万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747742
• 关键词: Superhydrophobic; icephobic; materials; biomedical; engineering

This Alliance International Catalyst grant application outlines our initiative to employ the superhydrophobic and icephobic materials developed lately at Simon Fraser University (SFU) for advanced biomedical engineering applications explored at National Taiwan University (NTU). Particularly, we are aiming at optimized manufacture of cryomicroneedles for drug delivery and cell transplantation through skin penetration. Cryomicroneedle is a new generation of microneedle technology developed recently that allows the intradermal delivery of living cells or drugs in a minimally invasive manner. The problem to be solved is to avoid the damage when detaching the cryomicroneedles from the specially designed and fabricated polydimethylsiloxane (PDMS) micromolds. In the past decade, we have made significant contributions in creating superhydrophobic materials/substrates via unconventional silanization reactions for the fabrication of more efficient microfluidic biochips and other industrial applications. The main objective of this initiative is to introduce superhydrophobic and icephobic materials to the cryomicroneedle molding process to help the microneedle formation and unloading, to engineer the surface composition and nanoscale structure of the micromolds prior to their use in making cryomicroneedles. From a broader viewpoint, this project interfaces advanced materials research at SFU (Chemistry Department and 4D Labs) and biomedical engineering studies at NTU (College of Biomedical Engineering); the establishment of such an interdisciplinary collaboration not only leads to new avenues to shape the biomedical applications of new materials and devices, but also offer unique opportunities for trainees from varied culture, discipline, and education status to gain experience and skills for their future careers in health care and medical settings nationwide.

这份联盟国际催化剂资助申请概述了我们将西蒙·弗雷泽大学(SFU)最近开发的超疏水和疏冰材料用于国立台湾大学(NTU)探索的先进生物医学工程应用的计划。特别是，我们的目标是优化制造冷冻微针，用于药物输送和通过皮肤渗透的细胞移植。冷冻微针是最近发展起来的新一代微针技术，它允许以微创的方式在皮内给药活细胞或药物。需要解决的问题是避免将低温微针从专门设计和制造的聚二甲基硅氧烷(PDMS)微模上拆卸时造成的损坏。在过去的十年里，我们通过非传统的硅烷化反应在创造超疏水材料/衬底方面做出了重大贡献，用于制造更高效的微流体生物芯片和其他工业应用。这一倡议的主要目标是将超疏水和疏水材料引入冷冻微针成型过程，以帮助微针的形成和卸载，并在用于制造冷冻微针之前设计微模的表面成分和纳米结构。从更广泛的角度来看，这个项目结合了SFU(化学系和4D实验室)的先进材料研究和NTU(生物医学工程学院)的生物医学工程研究；这种跨学科合作的建立不仅带来了塑造新材料和设备的生物医学应用的新途径，而且为来自不同文化、学科和教育背景的学员提供了独特的机会，为他们未来在全国范围内的医疗保健和医疗环境的职业生涯获得经验和技能。