DNA/RNA Synthesizer for Nucleic Acid Chemistry

核酸化学和生物学领域的重大发展巩固了核酸疗法在现代医学前沿的地位。化学合成寡核苷酸是目前公认的继小分子和抗体之后的第三大药物发现平台。此外，合成DNA和RNA为研究关键的结构-功能关系提供了有价值的探针，为我们提供了重要的生物机制和过程的分子水平的见解。本申请要求的自动化DNA/RNA合成器（或“基因机器”）是同时生产多个DNA和RNA链的全球黄金标准，其规模允许对其三维结构和治疗活性进行系统评估。我们确定的仪器是独一无二的，因为它允许研究人员独立合成多条链，同时结合多达20个DNA/RNA修饰，这将帮助我们筛选具有最理想特性的候选物，用于我们在治疗和结构分析中的应用。使用该仪器训练的学生和研究人员将获得对DNA/RNA结构和生物学的新见解，并获得合成，分析技能和策略方面的专业知识，以将候选分子开发成有用的药物。这种培训对化学和药物化学领域的全球雇主很有价值，特别是在DNA/RNA治疗领域不断扩大的情况下。

Significant developments made in the fields of nucleic acid chemistry and biology have solidified nucleic acid therapeutics' presence at the forefront of modern medicine.  Chemically synthesized oligonucleotides are now recognized as the third major drug discovery platform, in addition to small molecules and antibodies. Additionally, synthetic DNA and RNA provide valuable probes to study key structure -function relationships that offer us molecular -level insights of important biological mechanisms and processes. The automated DNA/RNA synthesizer (or "gene machine") requested in this application is the worldwide gold standard for producing multiple DNA and RNA strands simultaneously and at a scale that permits systematic evaluation of their three- dimensional structure and therapeutic activity. The instrument we have identified is unique because it allows for researchers to synthesize multiple strands independently, while incorporating up to 20 DNA/RNA modifications that will help us screen for the candidates with the most desirable properties for our applications in therapeutics and structural analysis. Students and researchers trained with this instrument will gain new insights into DNA/RNA structure and biology, and gain expertise in synthesis, analytical skills, and strategies to develop candidate molecules into useful drugs. This training is valuable to employers worldwide in the areas of chemistry and medicinal chemistry, especially as the field of DNA/RNA therapeutics continues to expand.