Synthesis and applications of RNA and RNA mimetics

RNA和RNA模拟物的合成及应用

• 批准号: 137143-2011
• 负责人: Damha, Masad
• 金额: $ 7.29万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=522311
• 关键词: Synthesis; applications; RNA; mimetics

Our laboratory has had a longstanding interest in the chemical synthesis and biochemical properties of nucleic acids (DNA and RNA). Our research goals include gaining a detailed understanding of inter- and intramolecular interactions between various nucleic acid components, or between nucleic acids and proteins as these key biochemical processes occur. We approach all of these studies through the use of chemically-modified nucleosides and oligonucleotides. We also devote an enormous effort to study nucleic acid structure. Our scientific approach combines solution and solid-phase syntheses, drug discovery, spectroscopic analysis, and molecular biology techniques. As such, the proposed work exposes students to nucleic acid chemistry and biology, analytical skills, and strategies to develop candidate molecules into useful drugs.

我们的实验室长期以来一直对核酸（DNA和RNA）的化学合成和生物化学性质感兴趣。 我们的研究目标包括详细了解各种核酸组分之间或核酸与蛋白质之间的分子间和分子内相互作用，因为这些关键的生化过程发生。 我们通过使用化学修饰的核苷和寡核苷酸来进行所有这些研究。我们还投入了巨大的努力来研究核酸结构。 我们的科学方法结合了溶液和固相合成、药物发现、光谱分析和分子生物学技术。 因此，拟议的工作使学生接触核酸化学和生物学，分析技能，以及将候选分子开发成有用药物的策略。