Bioinspired monomers for improved dental hard tissue-resin interfacial bonding

用于改善牙科硬组织-树脂界面粘合的仿生单体

基本信息

  • 批准号:
    RGPIN-2018-06489
  • 负责人:
  • 金额:
    $ 4.08万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Discovery Grants Program - Individual
  • 财政年份:
    2022
  • 资助国家:
    加拿大
  • 起止时间:
    2022-01-01 至 2023-12-31
  • 项目状态:
    已结题

项目摘要

The most employed treatment for decayed teeth is restoration with resin filling materials. Bonding agents are used to make resin fillings adhere to tooth. Resins are also used in cosmetic dentistry, crown cementation, and restorations of eroded teeth. Longevity of resin fillings is considered low with an average of 7 years. The replacement of resin fillings accounts for 75% of all procedures performed in general dentistry, of which 60% are due to failures at tooth-filling interface. This happens mainly because during bonding procedure it is essential that the tooth mineral is dissolved by acids exposing the organic component of the tooth. The organic component has enzymes that are secreted in a dormant form but get activated by acids, and once activated are able to self-degrade tooth structure. Attempts to improve the chemical composition of bonding agents, by adding naturally derived anti-enzymatic compounds (such as a catechin) to its formulations have been made. However, because such compounds are passively added to the bonding agents, they are also quickly released, limiting their activity. The overall objective of this research program is to develop and test three novel materials, where the catechin is chemically and permanently bound to the bonding agent. The objectives of this grant are: (1) To synthesize and characterize catechin modified dental adhesives; (2) To investigate mechanisms of anti-enzymatic activity produced by catechin modified dental adhesives; and (3) To evaluate long-term tooth to filling bond strength and tooth-resin interfacial integrity obtained by bonding agents based on modified dental adhesives. By perfecting the formulation of these novel materials through different challenges and tests we expect to considerably improve the success rates of dental filling procedures.
目前最常用的治疗方法是用树脂充填材料进行修复。粘结剂是用来使树脂填充物粘附在牙齿上的。树脂也用于牙科美容、牙冠粘固和腐蚀牙齿的修复。树脂填充物的寿命被认为较低,平均为7年。树脂充填物的更换占牙科总手术的75%,其中60%是由于牙齿充填界面的失败。这主要是因为在粘接过程中,牙齿矿物质必须被酸溶解,从而暴露牙齿的有机成分。有机成分含有以休眠形式分泌但被酸激活的酶,一旦激活就能够自我降解牙齿结构。已经尝试通过将天然衍生的抗酶化合物(例如儿茶素)添加到其制剂中来改善粘合剂的化学组成。然而,由于这些化合物被动地添加到粘合剂中,它们也会迅速释放,从而限制了它们的活性。该研究计划的总体目标是开发和测试三种新材料,其中儿茶素与粘合剂化学永久结合。本研究的目的是:(1)合成和表征儿茶素改性牙科粘合剂;(2)研究儿茶素改性牙科粘合剂产生抗酶活性的机制;(3)评价基于改性牙科粘合剂的粘结剂获得的长期牙齿-填充物粘结强度和牙齿-树脂界面完整性。通过不同的挑战和测试来完善这些新型材料的配方,我们希望能够大大提高牙科填充手术的成功率。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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Prakki, Anuradha其他文献

Functionalized epigallocatechin gallate copolymer inhibit dentin matrices degradation: Mechanical, solubilized telopeptide and proteomic assays
  • DOI:
    10.1016/j.dental.2018.08.297
  • 发表时间:
    2018-11-01
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Prakki, Anuradha;Xiong, Yaoyang;Stauroullalzis, Alexander Terry
  • 通讯作者:
    Stauroullalzis, Alexander Terry
Synergistic antimicrobial potential of EGCG and fosfomycin against biofilms associated with endodontic infections.
  • DOI:
    10.1590/1678-7757-2022-0282
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Duque, Cristiane;Souza, Amanda Caselato Andolfatto;Aida, Kelly Limi;Pereira, Jesse Augusto;Caiaffa, Karina Sampaio;Santos, Vanessa Rodrigues dos;Cosme-silva, Leopoldo;Prakki, Anuradha
  • 通讯作者:
    Prakki, Anuradha
Water distribution in dentin matrices: bound vs. unbound water.
  • DOI:
    10.1016/j.dental.2014.12.007
  • 发表时间:
    2015-03
  • 期刊:
  • 影响因子:
    5
  • 作者:
    Agee, Kelli A.;Prakki, Anuradha;Abu-Haimed, Tariq;Naguib, Ghada H.;Abu Nawareg, Manar;Tezvergil-Mutluay, Arzu;Scheffel, Debora L. S.;Chen, Chen;Jang, Seung Soon;Hwang, Hyea;Brackett, Martha;Gregoire, Genevieve;Tay, Franklin R.;Breschi, Lorenzo;Pashley, David H.
  • 通讯作者:
    Pashley, David H.
Properties of dental resins submitted to pH catalysed hydrolysis
  • DOI:
    10.1016/j.jdent.2012.09.012
  • 发表时间:
    2012-12-01
  • 期刊:
  • 影响因子:
    4.4
  • 作者:
    Cilli, Renato;Pereira, Jose Carlos;Prakki, Anuradha
  • 通讯作者:
    Prakki, Anuradha
Effect of protease inhibitor specificity on dentin matrix properties

Prakki, Anuradha的其他文献

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{{ truncateString('Prakki, Anuradha', 18)}}的其他基金

Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2021
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2020
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2019
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2018
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual

相似海外基金

Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2021
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual
Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery
使用具有动态重排和自我恢复能力的单体增强牙科粘合剂
  • 批准号:
    10432008
  • 财政年份:
    2020
  • 资助金额:
    $ 4.08万
  • 项目类别:
Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery
使用具有动态重排和自我恢复能力的单体增强牙科粘合剂
  • 批准号:
    10174916
  • 财政年份:
    2020
  • 资助金额:
    $ 4.08万
  • 项目类别:
Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery
使用具有动态重排和自我恢复能力的单体增强牙科粘合剂
  • 批准号:
    10055545
  • 财政年份:
    2020
  • 资助金额:
    $ 4.08万
  • 项目类别:
Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2020
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual
Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery
使用具有动态重排和自我恢复能力的单体增强牙科粘合剂
  • 批准号:
    10625355
  • 财政年份:
    2020
  • 资助金额:
    $ 4.08万
  • 项目类别:
Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2019
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual
Bioinspired monomers for improved dental hard tissue-resin interfacial bonding
用于改善牙科硬组织-树脂界面粘合的仿生单体
  • 批准号:
    RGPIN-2018-06489
  • 财政年份:
    2018
  • 资助金额:
    $ 4.08万
  • 项目类别:
    Discovery Grants Program - Individual
Development of Secondary and Tertiary Thiol Monomers for Thiol-ene Dental Restorative Materials
硫醇烯牙科修复材料用二级和三级硫醇单体的开发
  • 批准号:
    9813506
  • 财政年份:
    2018
  • 资助金额:
    $ 4.08万
  • 项目类别:
Monomers and nanogel to improve adhesive resin structural integrity/durability
用于提高粘合剂树脂结构完整性/耐久性的单体和纳米凝胶
  • 批准号:
    8581810
  • 财政年份:
    2013
  • 资助金额:
    $ 4.08万
  • 项目类别:
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