THE INFLUENCE OF SEX AND PUBERTY ON KNEE JOINT NEUROMUSCULAR CONTROL, LOADING AND STABILISATION

性别和青春期对膝关节神经肌肉控制、负荷和稳定性的影响

• 批准号: RGPIN-2020-06250
• 负责人: Benoit, Daniel
• 金额: $ 4.01万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=757072
• 关键词: INFLUENCE; SEX; PUBERTY; KNEE; JOINT

Over the past six years, my multidisciplinary team of trainees has developed new methods to improve the measurement and application of research related to knee joint kinematics, neuromuscular control and loading in the healthy adult population. This has led to a fully funded Visiting Professorship (U of Copenhagen) and over 50 presentations, 26 publications (including an Editor's Pick), 5 submitted manuscripts, 3 prize nominated theses, and an award-winning 3D printed knee brace. This next phase of my research program focuses on the paediatric population, in part due to the lack of research surrounding their neuromuscular control strategies during functionally demanding tasks, and in part due to the significant and continuous rise of knee injuries in the early pubescent population. For context, as many as 1 in 20 young competitive basketball or soccer players will sustain a significant knee injury per year of exposure, yet there is no consensus on sex and developmental activation and movement strategies in the normally developing population and paediatric knee injury mechanisms are poorly defined. Furthermore, existing literature on puberty- and sex-related changes in neuromuscular control and biomechanics is derived from cross-sectional cohort studies, limiting the level of evidence used to form our understanding of developmental changes (i.e. cause and effect cannot be assumed). I therefore propose a longitudinal program to investigate the Influence of Sex and Puberty on Knee Joint Neuromuscular Control, Loading and Stabilisation through puberty. We will assess 160 young healthy males and females from T1 (age 11/12) to T2 (age 13/14) with the following aims: (1)Describe the functional capacity of pre- and early pubescent males and females: We will measure functional capacity including spatio-temporal measures during hoping tasks, strength, muscular endurance, neuromuscular control and whole body kinematics and kinetics during landing tasks. (2)Model knee ligament and contact forces in pre- and early pubescent males and females: We will develop a novel, scalable MRI-based neuromusculoskeletal model to contrast paediatric joint and ligament forces from T1 and T2. (3)Identify knee joint control strategies in pre- and early pubescent males and females: We will use a combination of principal component and linear discriminant analyses on the pooled Aim1 and 2 data to extract variables that predict optimal or failed knee joint control strategies during landing tasks. My trainees will gain transferable skills in movement analysis, data science and modeling while working with a diverse young population from our community. We will provide insights into potential sex differences and injury mechanisms in an increasingly vulnerable population. My long term goal of characterising the evolution of functional capacity, neuromuscular control and knee stabilisation through puberty will be achieved with a third evaluation (age 15/16) beyond this application.

在过去的六年中，我的多学科实习生团队开发了新方法，以改进健康成年人群中与膝关节运动学、神经肌肉控制和负荷相关的研究的测量和应用。这导致了全额资助的客座教授（哥本哈根大学）和超过 50 场演讲、26 份出版物（包括编辑精选）、5 份提交的手稿、3 篇获奖提名论文以及获奖的 3D 打印护膝。我的研究计划的下一阶段重点关注儿科人群，部分原因是缺乏围绕其在功能要求较高的任务中的神经肌肉控制策略的研究，部分原因是青春期早期人群中膝盖损伤的显着且持续上升。就背景而言，每年有多达二十分之一的年轻竞技篮球或足球运动员会遭受严重的膝关节损伤，但对于正常发育人群中的性和发育激活以及运动策略尚未达成共识，并且儿童膝关节损伤机制的定义也很模糊。此外，关于青春期和性别相关的神经肌肉控制和生物力学变化的现有文献来自横断面队列研究，限制了用于形成我们对发育变化的理解的证据水平（即不能假设因果关系）。因此，我提出了一项纵向计划来研究性别和青春期对青春期膝关节神经肌肉控制、负荷和稳定的影响。我们将评估 160 名年轻健康男性和女性，从 T1（11/12 岁）到 T2（13/14 岁），目标如下：（1）描述青春期前和青春期早期男性和女性的功能能力：我们将测量功能能力，包括希望任务期间的时空测量、力量、肌肉耐力、神经肌肉控制以及着陆期间的全身运动学和动力学 任务。 (2) 对青春期前和青春期早期男性和女性的膝关节韧带和接触力进行建模：我们将开发一种新型、可扩展的基于 MRI 的神经肌肉骨骼模型，以对比 T1 和 T2 的儿童关节和韧带力。 (3) 确定青春期前和青春期早期男性和女性的膝关节控制策略：我们将对汇总的 Aim1 和 2 数据使用主成分和线性判别分析相结合，以提取预测着陆任务期间最佳或失败膝关节控制策略的变量。 我的学员将在与我们社区的多元化年轻人一起工作的同时，获得运动分析、数据科学和建模方面的可转移技能。我们将深入了解日益脆弱的人群中潜在的性别差异和伤害机制。我的长期目标是描述青春期功能能力、神经肌肉控制和膝关节稳定性的演变特征，这将通过本次应用之外的第三次评估（15/16 岁）来实现。