Phase 2- A collaboration between the University of Ottawa and Vivosonic towards the use of the Integrity V500 in the quantitative evaluation of tinnitus

耳鸣是一种改变生活的疾病，影响着36万加拿大人，给加拿大经济带来了数亿美元的经济负担。虽然目前使用主观工具来诊断**情况，但还没有可靠的临床客观测量方法。Engage Plus的目的是与我们的合作伙伴Vivosonic Inc.共同开发区分耳鸣和正常听力人群所需的**硬件、算法和测试协议**。我们的成功将导致一种创新的临床测量工具。**我们的研究团队开发了一种创新的噪声间隙技术，理论上可以应用于**人类进行耳鸣检测。Vivosonic公司制造可记录**从听神经到脑干的电反应的Integrity(TM)V500系统，称为听性脑干反应(ABR)。**他们的技术在市场上是独一无二的，因为它使用专利算法、预滤波、现场放大和**数字传输，共同将录音中捕获的噪音水平降至最低。在我们的第一阶段参与**中，我们创建了一个原型和时间处理测试，并在正常人群中进行了试验。我们确认**他们的平台非常适合应用我们的Gap-in-Noise协议，并在**噪声(临床相关)条件下捕获微小的ABR变化。这两个因素对于开发临床上可行的**测量系统至关重要。**在这个Engage Plus中，我们的目标是对耳鸣人群分类所需的硬件、时间分析和收集**协议进行修改。我们将使用一个小的静默间隔**改变持续时间的噪声刺激来测量听神经的反应，在方案期间改变刺激频率和间隙宽度**范围。改进后的系统将提取我们新的ABR指标，这些指标将用Vivosonic专有的信号调节和基于机器学习的分类方法处理**，以...

Tinnitus is a life-altering condition that affects 360,000 Canadians and represents an economic burden of**hundreds of millions to the Canadian economy. While subjective tools are currently used to diagnose the**condition, no reliable clinical objective measure exists. The purpose of this Engage Plus is to develop the**hardware, algorithms and testing protocol required to discriminate tinnitus from the normal hearing population**with our partner, Vivosonic Inc. Our success will lead to an innovative clinical measurement tool.**Our research team has developed an innovative gap-in-noise technique that could theoretically be applied to**humans for tinnitus detection. Vivosonic Inc manufacturers the Integrity(TM) V500 system which records**electrical responses from the auditory nerve to the brainstem, known as the auditory brainstem response (ABR).**Their technology is unique on the market as it uses a patented algorithm, pre-filter, onsite amplification, and a**digital transmission that, together, minimize the level of noise captured in the recording. In our Phase-1 Engage**we created a prototype and temporal processing test that was piloted on a normal population. We confirmed**that their platform is ideal for application of our gap-in-noise protocol and capturing small ABR changes under**noisy (clinically relevant) conditions. These two factors are critical for developing a clinically viable**measurement system.**In this Engage Plus our goal is to introduce modifications to the hardware, temporal analysis and collection**protocol required to classify the tinnitus population. We will use a noise stimulus with small silent intervals of**altering durations to measure the response of the auditory nerve, modifying stimulus frequency and gap width**ranges during the protocol. The modified system will extract our novel ABR measures, these will be treated**with Vivosonic's proprietary signal conditioning and machine learning based classification approach to...