Mechanics of Shoulder Demands and Associated Tissue Responses

肩部需求的机制和相关的组织反应

• 批准号: RGPIN-2022-03322
• 负责人: Dickerson, Clark
• 金额: $ 3.35万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=757830
• 关键词: Mechanics; Shoulder; Demands; Associated; Tissue

Shoulder function is crucial for human life, but many uncertainties remain concerning how the shoulder enables a broad spectrum of activities without being damaged. In our modern world, damage to vulnerable shoulder tissues may cause decreased fulfillment, independence, quality of life, and productivity. The guiding vision of my research program is to produce needs-based societal advances by clarifying how shoulder tissues are damaged. Success in achieving this vision can improve many aspects of working and daily life. Shoulders are complex mechanical systems. This complicates simplified conclusions about how they operate and fail. My research aims to address fundamental gaps in shoulder mechanics through three objectives, which cooperatively support development of biomechanical models to assess potential damage scenarios. Objective 1: Unprecedented insight into intramuscular recruitment patterns: Muscles of the shoulder have often been simplified regarding their contributions to movement and functional task performance. Expanded characterization of regions of the pectoralis major and latissimus dorsi, and subsequently the rhomboids and trapezius, will clarify the roles of these multi-function muscles and resolve questions surrounding neuromuscular control at the sub-muscle level. Objective 2: Fatigue responses in the context of external arm support: Muscular fatigue is a primary factor in altering typical shoulder mechanics. We will use new methods to define changes in arm motions, combined with advanced muscle activity data to characterize fatigue progression. This evaluation will also consider the efficacy of external arm support, which is emerging as a popular intervention, via assessing the efficacy of an exoskeleton to reduce fatigue responses across a variety of task types. Objective 3: Refining tendon damage mechanisms for realistic exposures: The consequences of real-world tendon loading caused by high arm mobility are unclear. We will expand work with our unique animal model setup by applying more intricate and realistic tendon loading profiles, including previously untested but dangerous bony contact and twisting forces. Producing this new data will help determine new applied strategies to avoid tendon damage. In summary, shoulder mechanics - from bone movement to specific tissue loads and failure modes - will be assessed with integrative, cutting edge approaches. The primary datasets produced will be used to enhance our advanced computational biomechanical model of the shoulder, increasing its accuracy and utility across many applications. Trainees exiting my program will have a powerful set of biomechanical and technical skills to contribute broadly in industry and academia alike. Ultimately, combining the fundamental shoulder mechanics insights gained and persistent pursuit of my vision of practical solutions will continue to translate into tangible strategies for maintaining shoulder and arm function for all Canadians.

肩关节功能对人类生活至关重要，但关于肩关节如何在不受损伤的情况下进行广泛的活动仍然存在许多不确定性。在我们的现代世界中，对脆弱的肩部组织的损伤可能会导致成就感，独立性，生活质量和生产力下降。我的研究计划的指导愿景是通过澄清肩部组织如何受损来产生基于需求的社会进步。成功实现这一愿景可以改善工作和日常生活的许多方面。肩膀是一个复杂的机械系统。这使得关于它们如何运作和失败的简单结论变得复杂。我的研究旨在通过三个目标来解决肩部力学的根本差距，这三个目标共同支持生物力学模型的开发，以评估潜在的损伤情况。目标一：前所未有的洞察肌内招募模式：肩部肌肉在运动和功能任务表现方面的贡献往往被简化。扩大表征的区域的胸大肌和背阔肌，随后菱形肌和阔肌，将澄清这些多功能肌肉的作用，并解决问题周围的神经肌肉控制在亚肌肉水平。目的2：外部手臂支撑环境下的疲劳反应：肌肉疲劳是改变典型肩部力学的主要因素。我们将使用新的方法来定义手臂运动的变化，结合先进的肌肉活动数据来表征疲劳的进展。这项评估还将考虑外部手臂支撑的功效，这是一种流行的干预措施，通过评估外骨骼在各种任务类型中减少疲劳反应的功效。目标三：细化肌腱损伤机制，以实现真实的暴露：由高手臂移动性引起的真实世界肌腱负荷的后果尚不清楚。我们将扩大我们独特的动物模型设置的工作，通过应用更复杂和现实的肌腱加载配置文件，包括以前未经测试，但危险的骨接触和扭转力。产生这些新数据将有助于确定避免肌腱损伤的新应用策略。总之，肩关节力学-从骨运动到特定组织载荷和失效模式-将采用综合、尖端方法进行评估。产生的主要数据集将用于增强我们先进的肩部计算生物力学模型，提高其在许多应用中的准确性和实用性。学员退出我的计划将有一套强大的生物力学和技术技能，在工业界和学术界广泛作出贡献。最终，结合所获得的基本肩部力学见解和对我的实用解决方案愿景的不懈追求，将继续转化为维持所有加拿大人肩部和手臂功能的切实战略。