Insights into poroelastic media flow
深入了解多孔弹性介质流
基本信息
- 批准号:RGPIN-2022-04727
- 负责人:
- 金额:$ 3.35万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2022
- 资助国家:加拿大
- 起止时间:2022-01-01 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Poroelastic materials consist of an elastic porous solid with fluid-filled pores, and in general this solid can show viscoelastic properties. Fluid flow in the porous matrix and deformation of this matrix are inherently coupled. We have recently developed a technique for measuring the strain field inside a poroeleastic material such as biological tissue with high spatial and temporal resolution. Other work typically performs macroscopic experiments on poroelastic materials and uses these results to identify parameters for lumped parameter models, analytical models or finite element analysis models of these materials. These models include assumptions for the description of the solid phase and for the permeability of the solid matrix as a function of strain or porosity. These models are difficult to validate as it is difficult to characterize the solid matrix independently for most materials. In the long term, this research program will develop expertise in the characterization, modelling and the design of poroelastic materials for applications in diverse areas such as biotechnology, robotics and the environment. Within the next 5 years of this research program we will develop methods to create poroelastic materials with tunable properties, and we will develop methods for the characterization of the individual components and the combined poroelastic materials including an adaptation of our strain field measurement method to these artificial materials. We will apply these tools to verify common poroelastic models and characterization methods, where we can compare the identified model parameters to independently measured material properties. The measured strain fields will help us understand the underlying physics at the microscopic level. We will also apply these tools to help elucidate phenomena reported in the literature that are still missing a generally agreed-on explanation such as the hysteretic behaviour of the flow resistance of a compacted poroelastic material for an increasing and decreasing flow rate. The findings of these studies will be applied to initial work on biological tissue samples (excised pig skin). The projects planned for this grant will involve 2 PhD students, 3 MASc students and 6 undergraduate students over the next 5 years of this program. These HQP will be selected following equitable hiring practices to allow for continued diversity in my team with demonstrated positive impact on innovations in our research. Beyond increasing our understanding of poroelastic materials, the proposed work will open new opportunities to expand this research program toward application areas such tissue engineering, filtration technology and human-robot interaction.
多孔弹性材料由具有充满流体的孔的弹性多孔固体组成,并且通常这种固体可以显示粘弹性性质。多孔基质中的流体流动和该基质的变形固有地耦合。我们最近开发了一种技术,用于测量多孔弹性材料,如生物组织内部的应变场具有高的空间和时间分辨率。其他工作通常在多孔弹性材料上进行宏观实验,并使用这些结果来识别这些材料的集总参数模型、分析模型或有限元分析模型的参数。这些模型包括固相的描述和作为应变或孔隙度的函数的固体基质的渗透性的假设。这些模型很难验证,因为对于大多数材料来说,很难独立地表征固体基质。 从长远来看,该研究计划将发展多孔弹性材料的表征,建模和设计方面的专业知识,用于生物技术,机器人和环境等不同领域的应用。在未来5年的研究计划中,我们将开发方法来创建具有可调特性的多孔弹性材料,我们将开发用于表征单个组件和组合多孔弹性材料的方法,包括将我们的应变场测量方法适应这些人工材料。我们将应用这些工具来验证常见的多孔弹性模型和表征方法,在那里我们可以比较确定的模型参数独立测量的材料性能。测量的应变场将帮助我们理解微观层面的基本物理。我们还将应用这些工具来帮助阐明文献中报道的现象,这些现象仍然缺少一个普遍认同的解释,例如压实多孔弹性材料的流动阻力的滞后行为,用于增加和减少流速。这些研究的结果将应用于生物组织样本(离体猪皮)的初步工作。 计划用于此补助金的项目将涉及2名博士生,3名MASc学生和6名本科生在未来5年的这一计划。这些HQP将根据公平的招聘实践进行选择,以允许我的团队继续保持多样性,并对我们的研究创新产生积极影响。除了增加我们对多孔弹性材料的理解外,这项工作还将为将这项研究计划扩展到组织工程、过滤技术和人机交互等应用领域提供新的机会。
项目成果
期刊论文数量(0)
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Stoeber, Boris其他文献
In vivo evaluation of a microneedle-based miniature syringe for intradermal drug delivery
- DOI:
10.1007/s10544-009-9311-y - 发表时间:
2009-10-01 - 期刊:
- 影响因子:2.8
- 作者:
Hafeli, Urs O.;Mokhtari, Amir;Stoeber, Boris - 通讯作者:
Stoeber, Boris
Characterization method for calculating diffusion coefficient of drug from polylactic acid (PLA) microneedles into the skin
- DOI:
10.1016/j.jddst.2020.102192 - 发表时间:
2021-02-10 - 期刊:
- 影响因子:5
- 作者:
Wu, Libo;Shrestha, Pranav;Stoeber, Boris - 通讯作者:
Stoeber, Boris
Lung Perfusion Imaging with Monosized Biodegradable Microspheres
- DOI:
10.1021/bm9010722 - 发表时间:
2010-03-01 - 期刊:
- 影响因子:6.2
- 作者:
Haefeli, Urs O.;Saatchi, Katayoun;Stoeber, Boris - 通讯作者:
Stoeber, Boris
Development and Validation of an Artificial Mechanical Skin Model for the Study of Interactions between Skin and Microneedles
- DOI:
10.1002/mame.201500320 - 发表时间:
2016-03-01 - 期刊:
- 影响因子:3.9
- 作者:
Ranamukhaarachchi, Sahan A.;Schneider, Thomas;Stoeber, Boris - 通讯作者:
Stoeber, Boris
Effect of poling time and grid voltage on phase transition and piezoelectricity of poly(vinyledene fluoride) thin films using corona poling
- DOI:
10.1088/0022-3727/46/28/285305 - 发表时间:
2013-07-17 - 期刊:
- 影响因子:3.4
- 作者:
Mahadeva, Suresha K.;Berring, John;Stoeber, Boris - 通讯作者:
Stoeber, Boris
Stoeber, Boris的其他文献
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{{ truncateString('Stoeber, Boris', 18)}}的其他基金
Microfluidics and Sensing Technology
微流控与传感技术
- 批准号:
CRC-2017-00041 - 财政年份:2022
- 资助金额:
$ 3.35万 - 项目类别:
Canada Research Chairs
Microfluidics And Sensing Technology
微流控与传感技术
- 批准号:
CRC-2017-00041 - 财政年份:2021
- 资助金额:
$ 3.35万 - 项目类别:
Canada Research Chairs
Characterization of non-Newtonian fluids at small length scales
小长度尺度非牛顿流体的表征
- 批准号:
RGPIN-2016-03814 - 财政年份:2021
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Characterization of non-Newtonian fluids at small length scales
小长度尺度非牛顿流体的表征
- 批准号:
RGPIN-2016-03814 - 财政年份:2020
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
Paper-based particulate matter sensors
纸基颗粒物传感器
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506926-2017 - 财政年份:2020
- 资助金额:
$ 3.35万 - 项目类别:
Strategic Projects - Group
Microfluidics and Sensing Technology
微流控与传感技术
- 批准号:
1000231712-2017 - 财政年份:2020
- 资助金额:
$ 3.35万 - 项目类别:
Canada Research Chairs
Preparation and Characterization of Piezoelectric Materials
压电材料的制备与表征
- 批准号:
RTI-2020-00349 - 财政年份:2019
- 资助金额:
$ 3.35万 - 项目类别:
Research Tools and Instruments
Microfluidics and Sensing Technology
微流控与传感技术
- 批准号:
1000231712-2017 - 财政年份:2019
- 资助金额:
$ 3.35万 - 项目类别:
Canada Research Chairs
Platform technology for blood diagnostics integrating microneedle blood sampling and quantum-dot based multiplexed assays
集成微针血液采样和基于量子点的多重检测的血液诊断平台技术
- 批准号:
523793-2018 - 财政年份:2019
- 资助金额:
$ 3.35万 - 项目类别:
Collaborative Health Research Projects
Characterization of non-Newtonian fluids at small length scales
小长度尺度非牛顿流体的表征
- 批准号:
RGPIN-2016-03814 - 财政年份:2019
- 资助金额:
$ 3.35万 - 项目类别:
Discovery Grants Program - Individual
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