Heart-lung interactions and the effect on cardiac and vascular mechanics

心肺相互作用及其对心脏和血管力学的影响

• 批准号: RGPIN-2018-04541
• 负责人: Eves, Neil
• 金额: $ 2.4万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=761796
• 关键词: Heart; lung; interactions; effect; cardiac

The heart, lungs and blood vessels are all connected and are critical to maintain blood pressure and blood flow for the delivery of oxygen and fuel to the organs and working muscles. Historically, researchers have used animal and human experiments to look at how changes in the lungs may affect the heart, primarily through mechanical changes in pressure and with forced breaths in or out. In contrast, a long-term goal of our laboratory is to enhance understanding of how the lungs, heart and blood vessels interact during spontaneous breathing and to examine how a change in one or more of these critical systems influence the mechanical and functional properties of the others. My laboratory and trainees have previously investigated fundamental aspects of how changes in negative pressures that occur in the chest, changes in lung volumes and changes in the size of blood vessels within our lungs influence the heart and the blood flow it generates. However, little is currently known regarding how the heart mechanically responds to these stressors, whether blood flow within the blood vessels effect how they function and whether changes in our blood vessels alter how the heart and lungs interact when they also impose a separate load to the heart. Utilizing sophisticated imaging techniques that allow us to look at how the heart rotates to fill and contract, we will examine how the mechanics of the heart respond to stressors imposed by the lungs and blood vessels. Furthermore, we will utilize a series of studies that alter: 1) the amount of blood in the heart, 2) the ability of the heart to contract and increase heart rate and 3) the load that the blood vessels place on the heart to try and determine the specific mechanisms by which the heart mechanically adjusts to different physiological changes within the lungs. The proposed research will greatly enhance our knowledge of how three essential systems work together and how the heart mechanically accommodates physiological stresses imposed from the lungs and blood vessels. Through these studies we also hope to identify potential new mechanisms that contribute to the changes in heart and blood vessels that occur when the human body is chronically challenged, as well as provide a high-quality learning environment for graduate students to enhance their training in human biology.

心脏，肺和血管都是连接在一起的，对于维持血压和血液流动以将氧气和燃料输送到器官和工作肌肉至关重要。 从历史上看，研究人员已经使用动物和人体实验来研究肺部的变化如何影响心脏，主要是通过压力的机械变化和强制呼吸。相比之下，我们实验室的长期目标是加强对肺，心脏和血管在自主呼吸过程中如何相互作用的理解，并研究这些关键系统中的一个或多个的变化如何影响其他系统的机械和功能特性。我的实验室和实习生以前研究了胸部负压变化、肺容积变化和肺内血管大小变化如何影响心脏及其产生的血流的基本方面。然而，目前对心脏如何机械地响应这些压力源知之甚少，血管内的血流是否影响它们的功能，以及当它们也对心脏施加单独的负荷时，我们血管中的变化是否会改变心脏和肺的相互作用。利用先进的成像技术，使我们能够看到心脏如何旋转，以填补和收缩，我们将研究心脏的力学如何应对肺部和血管施加的压力。此外，我们将利用一系列研究来改变：1）心脏中的血液量，2）心脏收缩和增加心率的能力，3）血管对心脏的负荷，以尝试确定心脏机械调节肺部不同生理变化的具体机制。这项研究将大大提高我们对三个基本系统如何协同工作以及心脏如何机械地适应来自肺部和血管的生理压力的认识。通过这些研究，我们还希望确定潜在的新机制，这些机制有助于人体长期受到挑战时发生的心脏和血管变化，并为研究生提供高质量的学习环境，以加强他们在人类生物学方面的培训。