Exercising the sleepy brain: protecting memories from the effects of sleep deprivation

锻炼困倦的大脑：保护记忆免受睡眠不足的影响

• 批准号: RGPIN-2022-05075
• 负责人: Roig, Marc
• 金额: $ 3.42万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=762192
• 关键词: Exercising; sleepy; brain; protecting; memories

Motivation: More than one third of adult Canadians are not getting enough sleep on a regular basis. These numbers are much worse among children and adolescents, for whom the effects of sleep loss have shown to have long-term consequences, negatively affecting their cognitive development and academic performance. Insufficient sleep costs Canadians 1.35% of the GDP ($21.4 billions) annually. Sleep insufficiency is associated with loss of work productivity and increases in traffic and work-related accidents, medical errors, and cognitive impairment. Sleep is essential to maintain neuroplasticity and cognition, and memory is one of the aspects of cognition most affected by sleep loss. Finding strategies to mitigate the impact of sleep insufficiency on neuroplasticity and memory is important. Animal studies demonstrate that exercise can protect memory and neuroplasticity from the effect of sleep deprivation. Whether exercise can also protect human memory is unknown. Objectives: The long-term objective of the research program presented in this application is to determine whether exercise can protect memory processing against the effects of sleep deprivation and whether the protective effect is mediated by neuroplasticity mechanisms. We propose three projects with three short-term objectives to determine whether: Project 1: individuals with a high cardio-respiratory fitness level are less susceptible to the effects of sleep deprivation on memory and the protective effect is associated with the capacity to activate brain networks during memory encoding; Project 2: a single bout of exercise performed before memory encoding promotes neuroplasticity changes that protect memory against sleep deprivation; Project 3: eight weeks of exercise training improve the function and structure of brain networks involved in memory processing, increasing the capacity to process memories under the effects of sleep deprivation. Impact: This research program will provide ground-breaking information to develop interventions to mitigate the deleterious effects of sleep loss on memory. Besides improving sleep quality, which could contribute to preserve cognitive function in individuals with sleep disorders, sessions of exercise strategically implemented could preserve memory function in sleep-restricted individuals or in people with shift works. The projects will also provide much needed information to understand how exercise impacts neuroplasticity processes underlying memory in the sleep deprived human brain. Identifying biomarkers of neuroplasticity susceptible to sleep loss and understanding how they respond to exercise will provide invaluable information to develop more targeted strategies to protect the structures and functions of the brain most affected by the deleterious effects of sleep deprivation.

动机：超过三分之一的加拿大成年人经常睡眠不足。这些数字在儿童和青少年中要糟糕得多，对他们来说，睡眠不足的影响已经显示出具有长期后果，对他们的认知发展和学习成绩产生负面影响。睡眠不足每年花费加拿大GDP的1.35%（214亿美元）。睡眠不足与工作效率的降低、交通和工作相关事故的增加、医疗错误和认知障碍有关。睡眠对维持神经可塑性和认知至关重要，而记忆是认知中受睡眠不足影响最大的方面之一。找到减轻睡眠不足对神经可塑性和记忆影响的策略是很重要的。动物研究表明，运动可以保护记忆和神经可塑性免受睡眠剥夺的影响。运动是否也能保护人类的记忆力尚不清楚。目的：本申请中提出的研究计划的长期目标是确定运动是否可以保护记忆处理免受睡眠剥夺的影响，以及这种保护作用是否由神经可塑性机制介导。我们提出了三个项目，有三个短期目标，以确定是否：项目1：具有高心肺健康水平的个体对睡眠剥夺对记忆的影响不太敏感，并且保护作用与在记忆编码过程中激活大脑网络的能力有关;项目2：在记忆编码之前进行一次运动，促进神经可塑性的变化，保护记忆免受睡眠剥夺;项目3：八周的运动训练改善了参与记忆处理的大脑网络的功能和结构，增加了在睡眠剥夺的影响下处理记忆的能力。 影响：这项研究计划将提供突破性的信息，以制定干预措施，以减轻睡眠不足对记忆的有害影响。除了改善睡眠质量，这可能有助于保持睡眠障碍患者的认知功能外，战略性实施的锻炼可以保持睡眠受限者或轮班工作者的记忆功能。这些项目还将提供急需的信息，以了解运动如何影响睡眠剥夺人脑中记忆的神经可塑性过程。识别易受睡眠不足影响的神经可塑性生物标志物并了解它们对运动的反应将提供宝贵的信息，以制定更有针对性的策略，以保护受睡眠剥夺有害影响最严重的大脑结构和功能。