Enhanced Neuroimaging Infrastructure for Innovative Visual Neuroscience

增强创新视觉神经科学的神经影像基础设施

• 批准号: RTI-2023-00465
• 负责人: Stevens, William
• 金额: $ 7.06万
• 依托单位: York University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=764151
• 关键词: Enhanced; Neuroimaging; Infrastructure; Innovative; Visual

York University has emerged as a world leader in cutting edge visual neuroscience research. York's Centre for Vision Research (CVR) is a leading institute worldwide engaged in neuroimaging research of human vision, and mentoring students and early career scientists in the most advanced vision neuroscience methods. York's NSERC funded Collaborative Research and Training Experience (CREATE) program focussing on "the Brain in Action" provides funding, resources, and international collaboration opportunities for highly qualified graduate and postdoctoral trainees. York's Vision: Science to Applications (VISTA) Program, funded by the Canada First Research Excellence Fund (CFREF), has invested millions of dollars to recruit world-leading scientists to York's team of vision neuroscience faculty; provide scholarships, fellowships, and training resources to graduate and postdoctoral trainees; and to upgrade the MRI scanner at the York MRI Facility to provide a state-of-the art neuroimaging research and training centre. In order to fully capitalize on these exceptional investments, enhanced neuroimaging tools and infrastructure are critically needed at the York MRI facility. This proposal focuses on `vision in action' - understanding visual functioning in real world contexts, from sensation to perception, and from perception to action. This innovative research program aims to advance our understanding of visual-motor integration; functional segregation of object, feature, and motion perception in the brain; neuroplasticity and visually guided learning; visually-guided navigation and spatial cognition; and visually-guided attention in aging and brain disease. Success depends on innovation, creating ecologically valid visual stimuli, from navigating real world 3D environments to precision visual-motor reach and grasp learning in the MRI scanner. However, since reopening the MRI Facility after a two-year closure due to the COVID-19 pandemic, multiple research projects are on hold until the required MRI related equipment can be replaced, upgraded, and/or acquired. The requested infrastructure includes: 1) an MRI compatible high-definition LCD screen and 2) a state-of-the-art remote eye-tracking system, necessary for precision-visual neuroscience research; and 3) high throughput MR data analysis computing infrastructure necessary for data harmonization, reproducibility, and open science. The overarching goal of these infrastructure investments is to enhance York's status as a global leader in visual neuroscience research and optimize the training of next-generation neuroscientists.

约克大学已成为尖端视觉神经科学研究的世界领先者。约克视觉研究中心 (CVR) 是一家全球领先的机构，致力于人类视觉神经影像研究，并为学生和早期职业科学家提供最先进的视觉神经科学方法的指导。约克大学 NSERC 资助的合作研究和培训体验 (CREATE) 项目专注于“行动中的大脑”，为高素质的研究生和博士后学员提供资金、资源和国际合作机会。约克视觉：科学应用（VISTA）计划由加拿大第一研究卓越基金（CFREF）资助，已投资数百万美元招募世界领先的科学家加入约克视觉神经科学团队；为研究生和博士后学员提供奖学金、助学金和培训资源；并升级约克核磁共振成像设施的核磁共振扫描仪，以提供最先进的神经影像研究和培训中心。为了充分利用这些特殊投资，约克 MRI 设施迫切需要增强的神经影像工具和基础设施。该提案的重点是“行动中的视觉”——理解现实世界中的视觉功能，从感觉到感知，从感知到行动。这项创新研究计划旨在增进我们对视觉运动整合的理解；大脑中物体、特征和运动感知的功能分离；神经可塑性和视觉引导学习；视觉引导导航和空间认知；以及对衰老和脑部疾病的视觉引导注意力。成功取决于创新，创造生态上有效的视觉刺激，从导航现实世界的 3D 环境到精确的视觉运动范围和 MRI 扫描仪中的掌握学习。然而，自从因 COVID-19 大流行而关闭两年后重新开放 MRI 设施以来，多个研究项目被搁置，直到可以更换、升级和/或购买所需的 MRI 相关设备。所需的基础设施包括：1）兼容 MRI 的高清 LCD 屏幕；2）最先进的远程眼动追踪系统，这是精确视觉神经科学研究所必需的； 3) 数据协调、可重复性和开放科学所需的高吞吐量 MR 数据分析计算基础设施。这些基础设施投资的总体目标是增强约克作为视觉神经科学研究全球领导者的地位，并优化下一代神经科学家的培训。