Illuminating the future of radiotherapy: 3D printed scintillation detectors

照亮放射治疗的未来：3D 打印闪烁探测器

• 批准号: RGPIN-2021-03650
• 负责人: Monajemi, ThalatTheresa
• 金额: $ 1.75万
• 依托单位: Dalhousie University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=764435
• 关键词: Illuminating; future; radiotherapy; 3D; printed

Plastic scintillators are near-ideal radiation detectors. They produce light when exposed to radiation, and the light can be collected with an optical reader. Their use is common in radiation therapy and particle physics for high energy x-ray or particle detections. To date, these detectors have not reached their full potential partly because of the limitations in shape and design. Plastic scintillators are available commercially in standard forms such as slabs, cubes, cylinders, spheres, or fibres. Production of good quality scintillators is a time-consuming process that requires specialized expertise, space, and equipment. Typically, a user would have to apply the scintillators as purchased. If customized shapes or light-output characteristics are desired, the purchase could be prohibitively costly.  Recent advances in 3D printing technology have resulted in producing a myriad of relatively low-cost consumer-grade printers. 3D printing is ideal for the rapid manufacturing of unique end products or small batches of products with bespoke or complex geometries. The users can rapidly create complex shapes that would otherwise be difficult, costly, and time-consuming to produce by traditional techniques. We aim to apply accessible 3D printing solutions to delivering high-quality and affordable plastic scintillators with custom-designed shape and light-output characteristics. Our immediate application is to use plastic scintillators for reading patients' radiation dose during radiation therapy treatments, the so-called in-vivo dose. Radiation therapy treatments are carefully planned, checked, and verified before the patient comes to the clinic. Still, once the treatment begins, there is most often no direct monitoring of the patient's radiation dose, which can be variable with the patient position, anatomical change, or inadvertent deviations in the treatment unit's performance. We want to integrate 3D printed scintillators into 3D printed devices worn by patients during treatments and read the light produced by radiation. Such routine in-vivo measurements would prevent accidents in radiation therapy, ensure that the intended dose is delivered, and, over time, serve to provide clinicians with invaluable information about the relationships between the outcomes and actual doses. The research and development in this project are also highly valuable in other fields besides medicine. This new technique could open up new possibilities for the field of particle detection. A successful 3D-printed plastic scintillator detector could pave the way for broader use of this technology in detector building, which could shake up the field of high-energy physics where large-scale custom-designed detectors have been prohibitively expensive for most applications. Such accessible large-scale and custom-designed detectors have immediate applications in detection of neutrinos.

塑料闪烁体是近乎理想的辐射探测器。当暴露在辐射下时，它们会发光，这些光可以用光学读取器收集。它们在放射治疗和高能x射线或粒子探测的粒子物理学中很常见。到目前为止，这些探测器还没有充分发挥其潜力，部分原因是形状和设计上的限制。塑料闪烁体在商业上有标准的形式，如平板、立方体、圆柱体、球体或纤维。生产高质量的闪烁体是一个耗时的过程，需要专门的专业知识、空间和设备。通常情况下，用户必须使用购买的闪烁体。如果需要定制的形状或光输出特性，购买可能会非常昂贵。最近3D打印技术的进步已经产生了无数相对低成本的消费级打印机。3D打印非常适合快速制造独特的最终产品或具有定制或复杂几何形状的小批量产品。用户可以快速创建复杂的形状，否则将是困难的，昂贵的，费时的生产传统技术。我们的目标是应用可访问的3D打印解决方案，提供高质量和价格合理的塑料闪烁体，具有定制设计的形状和光输出特性。我们的直接应用是使用塑料闪烁体来读取患者在放射治疗期间的辐射剂量，即所谓的体内剂量。在病人来到诊所之前，放射治疗是经过仔细计划、检查和验证的。然而，一旦开始治疗，通常没有直接监测病人的辐射剂量，这可能会随着病人的体位、解剖变化或治疗单位性能的无意偏离而变化。我们希望将3D打印闪烁体集成到患者在治疗期间佩戴的3D打印设备中，并读取辐射产生的光。这种常规的体内测量可以防止放射治疗中的意外，确保预期剂量的传递，并且随着时间的推移，为临床医生提供关于结果与实际剂量之间关系的宝贵信息。该项目的研究和开发在医学以外的其他领域也具有很高的价值。这项新技术为粒子探测领域开辟了新的可能性。一个成功的3d打印塑料闪烁体探测器可以为该技术在探测器建筑中的广泛应用铺平道路，这可能会动摇高能物理领域，在这个领域，大型定制设计的探测器对于大多数应用来说都过于昂贵。这种可访问的大规模和定制设计的探测器可以立即应用于中微子的探测。