Understanding how a novel mutation in matrix Gla protein causes skeletal anomalies
了解基质 Gla 蛋白的新突变如何导致骨骼异常
基本信息
- 批准号:489768
- 负责人:
- 金额:$ 44.58万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Operating Grants
- 财政年份:2023
- 资助国家:加拿大
- 起止时间:2023-09-01 至 2028-09-01
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Matrix Gla protein (MGP) acts as a potent inhibitor of soft tissue calcification in vascular and cartilaginous tissues. The complete loss of this protein in humans leads to calcification of almost all cartilage tissues, and some vascular tissues. Interest
基质Gla蛋白(MGP)是血管和软骨组织中软组织钙化的有效抑制剂。这种蛋白质在人体中的完全丢失会导致几乎所有软骨组织和一些血管组织的钙化。兴趣
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Murshed Monzur其他文献
Murshed Monzur的其他文献
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{{ truncateString('Murshed Monzur', 18)}}的其他基金
Understanding the pathophysiology of Keutel Syndrome: A path towards cure
了解科伊特尔综合征的病理生理学:治愈之路
- 批准号:
406805 - 财政年份:2019
- 资助金额:
$ 44.58万 - 项目类别:
Operating Grants
Midface hypoplasia caused by cartilage calcification: A mechanistic study with translational implications
软骨钙化引起的中面部发育不全:具有转化意义的机制研究
- 批准号:
402216 - 财政年份:2019
- 资助金额:
$ 44.58万 - 项目类别:
Operating Grants
Understanding the mechanism of vascular elastocalcinosis and its prevention by MGP
了解血管弹力钙质沉着症的机制及其 MGP 的预防
- 批准号:
409272 - 财政年份:2019
- 资助金额:
$ 44.58万 - 项目类别:
Operating Grants
Molecular mechanisms underlying the vascular calcification phenotype in matrix gla protein-deficient mice
基质gla蛋白缺陷小鼠血管钙化表型的分子机制
- 批准号:
255106 - 财政年份:2012
- 资助金额:
$ 44.58万 - 项目类别:
Operating Grants
34th Annual Meeting of The Society of Craniofacial Genetics
第34届颅面遗传学学会年会
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228098 - 财政年份:2011
- 资助金额:
$ 44.58万 - 项目类别:
Miscellaneous Programs
Role of a neutral sphingomyelinase as a novel regulator of skeletal mineralization
中性鞘磷脂酶作为骨骼矿化的新型调节剂的作用
- 批准号:
190524 - 财政年份:2009
- 资助金额:
$ 44.58万 - 项目类别:
Operating Grants
Role of a neutral sphingomyelinase as a novel regulator of skeletal mineralization
中性鞘磷脂酶作为骨骼矿化的新型调节剂的作用
- 批准号:
176423 - 财政年份:2008
- 资助金额:
$ 44.58万 - 项目类别:
Operating Grants
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