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Understanding how a novel mutation in matrix Gla protein causes skeletal anomalies

Understanding how a novel mutation in matrix Gla protein causes skeletal anomalies
了解基质 Gla 蛋白的新突变如何导致骨骼异常
批准号：
489768
负责人：
Murshed Monzur
金额：
$44.58万
依托单位：
Shriners Hospital for Children (Montral)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2028-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=489768&lang=en
关键词：
Apoptosis Bone Remodeling Chondrogenesis Endoplasmic Reticulum Stress Histomorphometry Matrix Gla Protein Micro-Ct Mouse Models Skeletal Development Skeletal Dysplasia

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中文摘要
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英文摘要
Matrix Gla protein (MGP) acts as a potent inhibitor of soft tissue calcification in vascular and cartilaginous tissues. The complete loss of this protein in humans leads to calcification of almost all cartilage tissues, and some vascular tissues. Interest
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