基于系统发育基因组学的疣猴亚科进化格局与形成机制研究

进化格局及其形成机制是进化生物学中最基本的科学问题和探讨生物多样性演变的根本问题。系统发育基因组学是从基因组层面上开展系统发育重建和进化格局研究。作为植食性最强的灵长类，疣猴亚科已成为探讨其起源、进化与适应机制的重要对象，目前由于分析手段和方法的不同，有关其各属种间以及种下和近缘种间的系统进化关系、进化格局及其形成机制仍存在诸多争议和不明之处。本项目以疣猴亚科为研究对象，通过定向序列捕获和高通量测序技术获得大量直系同源基因数据，利用系统发育基因组学方法，重建系统发育历史，从而揭示疣猴亚科的起源、进化格局及其形成机制。

Evolutionary pattern and its mechanism not only are basic science question in evolutionary biology, but also are critical and fundamental way to explore the evolution of biodiversity. The evolutionary process and history could be achieved by the reconstruction of phylogenetic relationships to clarify its evolutionary pattern and mechanism. The phylogenomics, which is one of the important trends in evolutionary biology, has been wildly used to try to resolve the reconstruction of phylogenetic relationships and evolutionary patterns in virtue of whole genomic sequences. The colobines (Primate Order, Cercopithecidae family, Colobinae subfamily) are a diverse clade of Old World primates and separated into Asian and African clades, which are also unique primates that use leaves rather than fruits and insects as their primary food source. At present, it has become the optimal object for studying of the origin of primates and its adaptive evolution because of almost exclusively herbivores and many other unique characters. In Colobinae subfamily, however, there are still many controversies and unknown causes about the phylogenetic relationships and formation mechanism of evolutionary pattern between Genus and species, because of different methodologies and molecular loci in previous studies. Especically, no any study was carried out to elucidate the phylogenetic relation, evolutionary patterns, and its formation mechanism within species and between the related species in this subfamily till now. This project, based on several known genome of primates and newly developed Sequence Targeted Capture technique and new high-throughput sequencing, aims to develop substantial orthologous genes and try to reconstruct the phylogenetic relationships so as to explore its evolutionary pattern and forming mechanism within Colobinae.