叶片衰老是植物叶片生长发育的最后阶段，是由叶龄依赖的内源发育信号和由外界环境刺激所启动的，涉及到多个分子层面的调控，尤其是转录和表观遗传调控。不同调控层面如何协调来影响叶片衰老是一个研究的难点，幸运的是多维组学数据积累和网络模块化分析为我们提供了新的思路。本研究将集成分析植物多组学数据，试图构建一个以表观基因组和转录组数据为主的、涵盖其它组学数据的多维组学整合与分析平台，着重于叶片衰老过程中转录和表观遗传调控机制的研究。该平台将包括以染色质状态为基础的表观基因组数据平台和以基因网络为主的转录调控分析平台。进而通过动态协同分析、功能富集分析等手段，我们将挖掘叶片衰老相关的关键功能模块，探索新的与叶片衰老相关的调控途径，对关键基因或特定的表观遗传位点进行功能验证。另外，通过跨物种表观基因组比较分析和基因功能模块比较分析，为农作物叶片衰老的调控机制研究提供参考，以期促进农作物叶片早衰问题的解决。

Leaf senescence is the final stage of plant leaf growth and development, which is initiated by age-dependent endogenous development signals and stimulated by external environment. There are multilayer molecular regulation of leaf senescence, especially the transcriptional and epigenetic regulation. It is very difficult to study about how the plants coordinate the different levels of regulation to affect leaf senescence. Fortunately, the accumulation of multi-dimensional omics data and the network-based modular analysis have provided us with new ideas. In this study, we will integrate plants multi-omics data, especially the epigenome and transcriptome data, to establish an effective integration and data-mining platform, mainly for the research about the transcriptional and epigenetic regulatory mechanism underlying leaf senescence. Our platform will cover chromatin states-based epigenome data integration and gene network-based transcriptional regulatory analyses. Then based on the multi-omics data integration platform together with dynamic collaborative analysis and functional enrichment analysis tools, we will search the leaf senescence related key function modules and explore new pathways, and might find some relevant new key genes or specific sites with chromatin modification. We will select several key regulatory factors for experimental validation. Furthermore, we will conduct comparative cross-species analysis for epigenome data, gene network and functional modules, to provide reference for studying the regulation mechanism of leaf senescence in different crops, which might promote to solve the important agricultural problem about the precocious leaf senescence.