在对血吸虫和宿主相互关系的研究中，学者们更多地关注于血吸虫感染后的免疫对疾病慢性化的影响，而对血吸虫感染致宿主的代谢障碍及相应的调节机制认识还远未深入。动物实验和人群流行病学资料均提示在血吸虫感染后，宿主的糖脂代谢可发生不同程度地减低。除虫卵肉芽肿所致肝损害外，虫卵所诱导的2型免疫应答在肝脏的糖脂代谢中可发挥着重要作用。在前期研究中，我们观察到miR-802的表达在日本血吸虫感染小鼠的肝脏中发生着显著的下调，伴随调节糖代谢的靶基因hnf1b的上升；且这种变化在血吸虫感染改善肥胖小鼠胰岛素抵抗的过程中表现得格外显著，因此我们推测miR-802可参与调节血吸虫感染中的宿主能量代谢异常。本项目继续研究miR-802如何受血吸虫感染的调节及改变miR-802的表达对宿主的代谢、免疫等影响，这为更好地阐明血吸虫感染致宿主糖脂代谢异常提供一定的理论依据。

In the studies of schistosome-host interaction, more attention has been paid to the effect on immune modulation to pathological changes in chronic schistosomiasis, while little is known about metabolic disorder and the involved regulation mechanism in the host. Some animal experiments and epidemiological data suggest that schistosome infection can cause the dysfunction of glucose and lipid metabolisms in the host. It is deduced that besides liver damage caused by egg granulomas, eggs-induced type 2 immune response also plays an important role in the dysfunction of glucose and lipid metabolisms. In our previous studies, we found that miR-802 expression was significantly down-modulated in the livers of mice with acute or chronic schistosome infection, with the up-regulated expression of hnf1b, a target gene of miR-802 involved in host’s glucose metabolism. Furthermore, more significant changes of miR-802 and its target gene hnf1b were observed in Leprdb/db mice with Schistosoma japonicum infection. Based on them, we will further study miR-802’s regulation on hepatic metabolism in Schistosoma japonicum infection and how to regulate the expression of miR-802 under hepatic immune microenvironment. This will help understand the relationship of schistosome infection, immune and metabolism.