动物实验和人群流行病学资料均提示在血吸虫感染后，宿主的糖脂代谢可发生不同程度地减低，这一现象可由“免疫代谢学”的理论给予一定的解释，即血吸虫感染过程中由虫卵所诱导的2型免疫应答和免疫调节可影响宿主的糖脂代谢。B细胞因负责机体的体液免疫，产生特异性抗体以及作为一类专职的抗原递呈细胞的角色为大多数学者所熟知，然而某些B细胞亚群也具有调节功能，可成为血吸虫感染后复杂免疫调节网络中的重要一员。有研究报道脂肪中为数不多的调节性B细胞可显著减轻肥胖中的脂肪炎症和胰岛素抵抗。因此，在前期对2型巨噬细胞和调节性T细胞的研究积累之上，本项目着重关注调节性B细胞参与日本血吸虫感染所致宿主代谢减低的能力，以及在免疫调控网络中免疫细胞之间的交互调节。本研究不仅从免疫代谢的角度深化我们对血吸虫与宿主相互作用的认识，而且可以增进对宿主整体免疫调节网络的理解。

Many animal experiments and epidemiological data indicated schistosome infection could reduce glucose and lipid metabolism in the host. To some degree, this phenomenon can be explained by the "immune metabolism" theory, that is, in the process of schistosome infection, egg-induced type 2 immune response and immune regulation can affect host glucose and lipid metabolism. It is well recognized that B cells are responsible for the production of antigen-specific antibodies in humoral immunity as well as a class of professional antigen-presenting cells. However, some B cell subsets have the regulatory function and participate in constituting the complex immune regulation network in the host with schistosome infection. It has been reported that a small number of regulatory B cells can significantly reduce adipose tissue inflammation and insulin resistance in obesity. Based on our previous studies on the immune regulation of M2 macrophages and regulatory T cells, this project will focus on the role of regulatory B cells involved in host metabolism in Schistosoma japonicum infection and the crosstalk between immune cells in the regulation network. This study will not only deepens our understanding of the interaction between schistosome and host, but also broaden our view of the host's immune regulatory network.