氢胺烷基化反应由于具有反应原子经济性及一步合成胺类化合物等特点受关注，在药物分子设计和天然产物的合成上有着巨大的应用潜能。近年来已成为国际上的研究热点之一。目前，该类反应存在催化剂不稳定，反应底物受限和反应机理不明确等问题。基于此，本项目通过调配配体的电子效应和空间效应发展包括后过渡金属在内的新型催化剂；建立高效的配位催化体系以拓展反应底物，增强该反应中烯烃和胺类化合物的普遍适用性，实现某些药物如盐酸西那卡塞片的高效合成；此外，通过对反应中间体捕捉和化学计算等手段探明反应的机理，总结可信的反应途径，为反应的进一步发展提供理论依据

Hydroaminoalkylation has attached much attention for it's excellent features of atom economy and one-step synthesis of amines,which was tremendous potential application in drugs design and natural products. In recent year, this area has become one of the hot topic. This program aims at the challenge of catalysts sensitive , substrates limit and unclear of reaction mechanism, develop including late transition metal new catalysts by adjusting the ligand electronic effects and steric effects, and then establish an efficient catalytic system expansion reaction substrate to achieve the reaction of olefins and amines, then achieve synthesis of Sensipar tablets. Furthermore, stablish an credible reaction mechanism via capturing the reaction intermediate and chemical calculation. which provide a theoretical basis for the further development of the reaction.