将芳香胺的C-N键切断并转化为新的化学键对于研究官能团化学转化、丰富芳香胺的化学，拓展芳香胺的应用范围都具有重要意义。本课题拟开展过渡金属络合物催化的芳香胺或铵盐C-N键的催化活化和转化研究。首先研究过渡金属络合物对芳基三甲基铵盐的催化活化以及与各种亲核试剂的作用，构建新的C-C键或C-杂原子键。在此基础上，我们将研究芳香胺在质子酸存在下其C-N键的催化活化和转化。也拟用Lewis酸来活化芳香胺的胺基，实现C-N键的催化断裂和转化。最后，我们将探索直接将芳香胺的C-N键催化活化，进而转化成新的化学键的方法。目标是发现有效的催化剂体系，能够高效地催化活化芳香胺或芳香铵盐的C-N键，构建新的C-C键或C-杂原子键，实现芳香胺的有效催化转化。

The investigation of transformation of arylamines through cleavage of the C-N bonds is very important to achieve functional group transformations, understand more about the properties of arylamines and extend the application scope of arylamines. This project intends to develop transition-metal-catalyzed methodology for the C-N bond activation and transformation of aromatic amines or ammonium salts. At first we will explore catalytic activation of aryltrimethylammonium salts and the following formation of C-C or C-heteroatom bonds by treatment with nucleophiles. Then we will study the catalytic activation and transformation of arylamines in the presence of a Br?nsted acid or a Lewis acid. Finally, we will try catalytic C-N bond activation and transformation of arylamines without the aid of an acid or an ortho functional group. The aim of this investigation is to achieve effective tranformation of arylamines through the C-N bond activation by developing new catalyst systems.