基于维蒂希试剂作为卡宾前体的金卡宾化学研究

金卡宾化学是有机合成化学中一项非常具有挑战性的课题。本项目拟尝试使用维蒂希试剂作为卡宾前体，与金催化剂在反应体系中原位形成金卡宾，通过对金卡宾中间体的捕获发展一系列化学键以及官能团构筑的新方法；研究中将同时开展维蒂希试剂作为卡宾前体与金催化剂的计量化反应研究，实现金卡宾的合成，开展金卡宾的金属有机化学性质研究。

Chemistry based on gold carbene intermediate is a fundamental challenge in current synthetic organic chemistry. This project aims to utilize wittig reagents as the carbene precursor to generate the gold carbene in situ, and thus develops new synthetic methodologies for the construction of new chemical bonds and chemical skeletons via capture of the gold carbene intermediate. In this study, we also attempt to synthesize the gold carbene complexes via stoichiometric reaction between wittig reagents and gold complexes, and then carry out studies on the chemical properties of the gold carbene complexes.