药物的研制有效延长了人类的生命周期，然而药物开发耗资巨大，为患者带来沉重负担和无法解决的副作用，为此，药物传输系统成为科研的焦点。细胞生存必须依赖离子平衡，近期文献发现氯离子可以诱导癌细胞凋亡。离子通道是离子进入细胞的必经之路，由于离子通道遭到破坏而导致的各类疾病已有报道。如果避开离子通道，利用纳米载体运输阴离子进入细胞将有效补充离子通道疾病导致的非离子平衡。我们在药载研究的基础上首次提出了阴离子载体的概念。将合成系列吸附氯离子和磷酸根离子的材料，利用纳米材料将阴离子运输到细胞，利用荧光信号完成离子的跟踪。在此基础上，研究细胞额外获取离子的能力以及离子对其周期和生存的影响。为了使材料对离子有足够吸附量，我们着力合成多个官能团吸附位点的材料，为了完成荧光跟踪，我们尝试自身荧光材料、嫁接荧光基团、嫁接阴离子探针等方式完成该项任务。课题将综合合成化学、分析化学和生物化学几方面的综合能力。

Medicine prolongs the human life in efficiency. However, successful development of a drug is costly and sometimes with side effect, which is too hard to bear for the patients. Drug delivery system with nanomaterials becomes the focus of research. Ion balance must be maintained for cell living and chloride ion was found to cause the apoptosis of cancer cells recently. Usually ion channel is the necessary factor for ion entering to cells and the damage of ion channel could cause various diseases. The supply of ions to cell with nanomaterials and avoiding to using ion channel could reduce the diseases with lacking of ions. Based on the previous work in our group of drug carriers, we first used the concept of anion carrier. In the project, a series of nanomaterials with multi groups would be synthesized to adsorb chloride and phosphate ions and then carry the ions enter into the cells. The fluorescence signal would be used to trace the ions by fluorescent matrix, or matrix modified with fluorescent group and the sensors for anion. The project would use the synthesis chemistry, analytical chemistry and biology knowledge together.