含氮/氧芳香化合物的不对称转化

含氮/氧芳香化合物具有原料易得、合成方便和性质稳定的特点。研究其不对称转化及其在药物分子和天然产物合成中的应用具有重要的理论意义和应用前景。本项目拟重点研究：1)含氮/氧芳香化合物的不对称氢化，合成手性的杂环化合物。主要的策略是通过发展底物活化、催化剂活化、捕获芳香化合物互变异构体和仿生不对称氢化；2）开展氟代含氮/氧芳香化合物的不对称氢化，合成氟代的手性杂环化合物；3）捕获芳香化合物氢化活性中间体的不对称串联反应研究；4） 基于酚类化合物衍生的亚甲基醌中间体及其类似物的不对称转化。主要开展不对称氢化、加成和环化反应研究。通过这些研究，开发具有自主知识产权的芳香化合物不对称转化技术，促进我国有机合成反应的研究与发展，推动在相关化学工业中的应用。

Due to ready availability, high stability and synthetic convenience, development of asymmetric transformations of arenes containing nitrogen and oxygen is highly desirable and still of great significance. In this project, we will focus on: 1) the development of asymmetric hydrogenation of arenes containing nitrogen and oxygen for rapid synthesis of chiral heterocycles. The strategies include substrate activation, catalyst activation, capture of tautomers of arenes, and biomimetic asymmetric hydrogenation; 2) asymmetric hydrogenation of fluorinated arenes for efficient synthesis of chiral fluorinated heterocycles; 3) exploring the asymmetric tandem reactions of hydrogenation intermediates of arenes; 4) exploring the asymmetric transformations of quinone methides derived from phenols. Transformations include asymmetric hydrogenation, addition, and cyclizations. The above methododlogy will be applied to synthesis of some natural occuring products and chiral drugs. By doing so, we will try to invent new asymmetric arene transformation technologies with self-owned intellectual property, and push forward the applications in the corresponding industries.