研究基于膦氧废弃物再利用的有机磷催化反应规律，并应用于杂环化合物合成。主要包括研究膦二卤化物/膦氧化物催化循环体系的脱水缩合反应规律并将其应用于杂环化合物的合成中，该方法由于使用催化量的磷试剂，可显著提高膦二卤化物脱水缩合反应的原子经济性；研究催化型分子内Wittig反应规律并将其应用于杂环化合物的合成中，该方法也使用了催化量的磷试剂，可提高分子内Wittig反应的原子经济性。通过本项目的研究，建立高效合成各种多取代杂环的新方法。如各种喹唑啉酮、噁唑、(苯并)呋喃、二氢吡咯酮、苯并氮杂卓酮、异喹啉酮、吲哚、(苯并)吡喃及三唑并三嗪酮等杂环化合物。本项目的研究，必将有利于基于膦氧废弃物再利用的有机磷催化反应在多取代杂环合成中的应用，并为多取代杂环的合成提供有效的新方法。

The organophosphorus catalysed reactions based on reuse of the phosphine oxide waste will be studied and applied in heterocyclic synthesis. It includes two strategies. Firstly the dehydration condensation based on phosphine dihalide/phosphine oxide catalytic cycle will be researched and used in synthesis of various heterocycles. The atom economy of this type of reaction will be promoted remarkably by using catalytic amount of phosphorus reagent. Then the catalytic intramolecular Wittig reaction will be investigated and applied in heterocyclic synthesis. The atom economy of intramolecular Wittig reaction will be promoted also by using catalytic amount of phosphorus reagent. Various new efficient synthetic methods for heterocycles will be established, including quinazolinones, oxazoles, (benzo)furans, dihydropyrrolones, benzazepinones, isoquinolinones, indoles, (benzo)pyrans, triazolotriazinones. The study of this item will be beneficial to the application of organophosphorus catalysed reactions based on reuse of the phosphine oxide waste in heterocyclic synthesis, and provides new efficient synthetic methods for multisubstituted heterocycles.