两种以上催化模式组合的不对称接力催化，连续催化串联反应，能够完成单个催化剂不能完成的不对称转化，具有从简单原料快速构建复杂手性分子的优势。另一方面，吡啶类叶立德的环化反应能够合成其他反应难以得到的含氮杂环类化合物，具有重要的理论意义和应用前景。但是，不对称催化这类反应得到手性含氮杂环化合物的报道极少。因此，本项目拟基于课题组特色的手性双氮氧催化剂，利用不对称接力催化的策略，以吡啶及其类似物为起始原料，发展金属/手性双氮氧-金属配合物的不对称接力催化体系，以实现吡啶类叶立德形成/环化的不对称串联反应。

Asymmetric relay catalysis , combining more than one catalytic models, can promote transformations that are not accessible through individual catalytic systems. Besides, it can construct rapidly complex molecules from simple starting materials without the isolation of intermediates, especially unstable intermediates. On the other hand, the cyclization reactions of pyridium type ylides are very valuable for their convenient synthesis of N-containing heterocyclic compounds that might be difficult to be obtained from other methods. However, in the catalytic asymmetric version, few examples about the cyclization of pyridium type ylides were reported. Therefore, based on the characteristic chiral N,N'-dioxide catalysts, the applicant and coworkers plan to apply the strategy of asymmetric relay catalysis and develop metal/N,N'-dioxide-metal complex catalytic systems to realize the diastereo- and enantioselective pyridium type ylide formation/cyclization reactions.