婴幼儿血管瘤(IH)是婴幼儿最常见肿瘤，虽然多数IH瘤体存在自发消退特性，但对其起源和病程影响因素了解甚少。研究显示大部分IH瘤体自发消退的特性和血管瘤内皮细胞的凋亡相关。我们早期研究发现IH增殖晚期和消退早期Fas/FasL信号通路活性明显增强，IH内皮细胞的凋亡和Fas/FasL信号通路密切相关。而miRNA可通过Fas/FasL信号通路影响凋亡过程。本研究拟通过miRNA芯片分析婴幼儿血管瘤各期miRNA表达谱变化，并与Fas/FasL信号通路活性作相关性分析确定相关miRNA为研究对象，在确定特定miRNA在IH中对Fas/FasL诱导的内皮细胞凋亡中作用的基础上，进一步研究各期IH血液中miRNA变化情况，并探讨其能否成为临床预判IH消退的血液学指标。这些特定miRNA的研究能够证实其在IH发病机制及病程演变中的重要作用，同时能够为临床判断IH病程变化提供理论依据。

Infantile hemangiomas(IH) are the most common tumors of infancy. Even though the life cycle of hemangiomas is well documented, their origin and factors controlling the life cycle remain unclear.Recently,there is a great development in IH research,in which the effect of VEGF signal pathway in proliferations of endothelial cells and the apoptosis in endothelial cells had been proved. We have proved that the activity of Fas/FasL signaling pathways was enhanced obviously at the late period of proliferation and the early period of involution,meanwhile the apoptosis of endothelial cells was closely related to Fas/FasL signaling pathway.we all know that miRNA could adjust the process of apoptosis through Fas/FasL signaling. Therefore,our study want to identify the miRNAs which close related to the activity of Fas/FasL signaling through miRNA chip.Make sure the effect of these miRNAs on the apoptosis of endothelial cells induced by Fas/FasL. Ascertain whether the miRNA could be an hematology index which can anticipate the involution of IH.With this study we can ascertain the effect of miRNA in hemangioma as well as providing the theoretical basis for anticipate the evolution course of IH.