双酚类化合物与不仅与双酚A具有相似的结构，被广泛应用于环氧树脂、聚碳酸酯和酚醛树脂等饮料、食品容器中，而且还具有相似的急性毒性、基因毒性和雌激素效应等，不属于安全的化学品，受到环境和食品领域的密切关注。鉴于儿童是双酚类化合物摄入的重要人群，本项目重点研究儿童体内双酚类化合物的暴露特征，研发具有超高类选择性的替代模板分子印迹聚合物固相萃取方法，同时结合同位素稀释-液相色谱串联质谱技术，建立双酚类化合物同时检测的高选择性、高灵敏度和高准确度分析方法，为开展儿童体内双酚类化合物暴露特征研究提供技术与方法支持。在此基础之上，重点开展不同年龄段儿童血清和尿液中双酚类化合物的暴露水平、分配规律等研究，填补我国在儿童体内双酚类化合物暴露研究方面的空白，为健康风险评估提供基础数据。同时，结合性激素、甲状腺激素水平，探究双酚类化合物暴露与儿童内分泌系统疾病之间的相关性。

With the similar structure to bisphenol A (BPA), bisphenol analogues are widely used in kinds of beverage and food containers which consists of epoxy resin, polycarbonate, phenol-formaldehyde resin etc. Not only that, due to the similar acute toxicity, genotoxicity and estrogenic effects to that of BPA, bisphenol analogues are not safe chemicals and have been paid close attention in environment and food fields. Considering children are an important exposure group, this study focuses on the body exposure of children to bisphenol analogues, explores high-selectivity solid-phase extract method with dummy template molecular imprinting polymers as sorbents, and combines with isotope dilution and liquid chromatography tandom mass spectroscope to develop a method with high selectivity, sensitivity and accuracy. It aims for providing technique and method supports for performing the exposure of children to bisphenol analogues. On the basis of the developed method, the following major work is to investigate the level, distribution of bisphenol analogues in serum and urine from children, which can fill in gaps in the exposure of children to bisphenol analogues and provide basic data for the health risk assesment. Meanwhile, this program can explore the relationships between bisphenol analogue exposure and the risk of endocrine system disease, by comparison with the levels of bishphenol analogures, sex hormones and thyroid hormones.