纳米农用药物的环境生物地球化学行为机制是开发高效纳米制剂和解决其环境污染的关键所在。纳米农用药物集传统农药与纳米材料于一身，在给人类带来巨大经济效益的同时，对生态环境的双重毒性也与日俱增，已对人类健康生存和持续繁衍构成严重威胁。本研究将环境地微生物学、生物地球化学、有机地球化学的理论与现代微量热、分子生物学、同位素示踪等先进的理化生技术相结合，通过研究纳米农用药物的降解途径，及其对环境地微生物和其生态的生长、内源和静息代谢的过程变化、功能基因表达和生物多样性的差异，在分子水平上，从能量和物质代谢角度揭示纳米农用药物与环境地微生物和其生态的相互作用机制，获取纳米农用药物在环境中迁移转化降解等地球化学信息，为纳米农用药物的环境生物地球化学行为及环境地微生物响应研究提供新的技术手段，并为开发高效的纳米制剂和利用环境地微生物资源来预警、防控和修复我国大量纳米农用药物的污染提供科学依据和技术支撑。

Nano-agricultural medicines, as both nano materials and traditional pesticides and herbicides, have created enormous beneficial economic impact on human lives, and at the same time, caused increasing toxicity to eco-systems and environments and are great threats to human health and reproductive system. Fully understanding their environmental behavior and biogeochemical mechanism is the first critical step to reduce their pollution and toxicity in the environment and develop new generation of nano-agricultural medicines with high efficiency but low toxicity. This study will integrate the theories of environmental geomicrobiology, biogeochemistry, and organic geochemistry with modern micro-thermal technology, physical and chemical techniques of molecular biology and isotope method, investigate the interaction and mechanism between nano-agricultural medicines and environmental geomicrobes at molecular level, endocrine metabolism, functional gene expression, and biodiversity, collect the geochemical information of enrichment, mineralization, degradation, transportation and transformation of nano-agricultural medicines in the environment, establish novel models of safety assessment on nano-agricultural medicines and environmental geomicrobial responses, and eventually provide unique scientific basis and technical support to develop new highly efficient nano-agricultural chemicals and utilize environmental geomicrobes to predict, assess, control, and remedy the environments polluted by nano-agricultural medicines in China.