间充质干细胞对细菌性急性肺损伤（ALI）有良好的保护作用，但其作用机制仍有待阐明。本项目将利用金葡菌诱导的小鼠ALI模型，阐明脂肪来源间充质干细胞（又称脂肪干细胞，ADSCs）对ALI保护作用的一种新机制：再生源蛋白IIIγ（RegIIIγ）介导了ADSCs的旁分泌作用。进一步研究ADSCs作为载体在肺内高表达RegIIIγ或外源导入RegIIIγ重组蛋白对金葡菌ALI的影响和免疫调控机制。同时通过ADSCs体金葡菌外感染模型，探索RegIIIγ的分子调控机制。本研究将为金葡菌感染性ALI的防治提供了新策略，为再生医学研究开辟新的思路。

Mesenchymal stem cells have shown protective effects on the acute lung injury (ALI)induced by bacteria, but their underlying mechanisms are still unclear.Using a mouse model of S.aurues-induced ALI, our research will illustrate a new protective mechanism for adipose-derived mesenchymal stem cells (ADSCs) in ALI: regenerating islet-derived protein IIIγ（RegIIIγ）mediates the paracrine effects of ADSCs.Furthermore,the effects of overexpression of RegIIIγin the lung by ADSCs or injecting exogenous recombinant RegIIIγ protein on S. aureus-induced ALI and its immune regulatory mechanisms will be explored. In addition,the molecular regulatory mechanism of RegIIIγ in ADSCs infected with S. aureus will be also investigated. Our study provides a novel strategy for the prevention and treatment of S. aureus-induced ALI, and opens up a new way for regenerative medical research.